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FLASH GENE
Symbol UBQLN3 contributors: SGE - updated : 04-05-2009
HGNC name ubiquilin 3
HGNC id 12510
Location 11p15.4      Physical location : 5.528.529 - 5.531.153
Synonym name ubiquilin-like 3
Synonym symbol(s) TUP-1
DNA
TYPE functioning gene
STRUCTURE 2.62 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC390053 11 similar to olfactory receptor MOR22-1 LOC390054 11 similar to odorant receptor HOR3beta5 OR52A1 11p15.5 olfactory receptor, family 52, subfamily A, member 1 OR51A1P 11p15.5 olfactory receptor, family 51, subfamily A, member 1 pseudogene LOC283110 11p15.4 similar to odorant receptor HOR3beta2 LOC283111 11p15.4 similar to odorant receptor HOR3beta1 HBB 11p15.5 hemoglobin, beta HBD 11p15.5 hemoglobin, delta HBBP1 11p15.5 hemoglobin, beta pseudogene 1 HBG1 11p15.5 hemoglobin, gamma A HBG2 11p15.5 hemoglobin, gamma G HBE1 11p15.5 hemoglobin, epsilon 1 OR51B4 11p15 olfactory receptor, family 51, subfamily B, member 4 LOC390056 11 similar to Olfactory receptor 51B4 (HOR5beta1) OR51B2 11p15 olfactory receptor, family 51, subfamily B, member 2 LOC390057 11 similar to MOR 5beta2 LOC390058 11 similar to HOR5Beta6 LOC390059 11 similar to HOR5Beta7 OR51J1P 11p15.3 olfactory receptor, family 51, subfamily J, member 1 pseudogene LOC390061 11 similar to Olfactory receptor 51Q1 LOC390062 11 similar to olfactory receptor MOR12-1 LOC390063 11 similar to Olfactory receptor 51I1 (HOR5beta11) LOC390064 11 similar to Olfactory receptor 51I2 (HOR5beta12) LOC390065 11 similar to HOR5Beta13 LOC390066 11 similar to Olfactory receptor 52D1 (HOR5beta14) UBQLN3 11p15 ubiquilin 3 MGC20470 11p15.4 hypothetical protein MGC20470 LOC338642 11p15.4 similar to RIKEN cDNA E030002O03 LOC390067 11 similar to seven transmembrane helix receptor LOC390068 11 similar to olfactory receptor MOR31-7 LOC143631 11p15.4 similar to olfactory receptor MOR31-6 LOC390069 11 similar to olfactory receptor MOR31-12 LOC340980 11p15.4 similar to seven transmembrane helix receptor TRIM6 11p15.4 tripartite motif-containing 6 TRIM34 11p15 tripartite motif-containing 34 TRIM5 11p15 tripartite motif-containing 5 TRIM22 11p15 tripartite motif-containing 22
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 2347 70.7 655 - 2000 10831842
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  specific
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ubiquitin-like domain in the N terminal region
  • two 93 AAs NP with five Asn-Pro motifs
  • a C terminal ubiquitin-associated (UBA) domains
    • HOMOLOGY
    interspecies homolog to murine Plic2
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • regulation of cell cycle progression during spermatogenesis
  • regulating cell survival during starvation
  • protects cells against starvation-induced cell death propagated by overexpression of mutant Alzheimer disease PS2N141I protein
  • a possible function of ubiquilin might be to bind and transport ubiquitinated proteins to autophagosomes
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • testis-specific cyclin A1 (CCNA1)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS