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FLASH GENE
Symbol UBQLN3 contributors: SGE - updated : 04-05-2009
HGNC name ubiquilin 3
HGNC id 12510
DNA
TYPE functioning gene
STRUCTURE 2.62 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 2347 70.7 655 - 2000 10831842
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  specific
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ubiquitin-like domain in the N terminal region
  • two 93 AAs NP with five Asn-Pro motifs
  • a C terminal ubiquitin-associated (UBA) domains
  • HOMOLOGY
    interspecies homolog to murine Plic2
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • regulation of cell cycle progression during spermatogenesis
  • regulating cell survival during starvation
  • protects cells against starvation-induced cell death propagated by overexpression of mutant Alzheimer disease PS2N141I protein
  • a possible function of ubiquilin might be to bind and transport ubiquitinated proteins to autophagosomes
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • testis-specific cyclin A1 (CCNA1)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS