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FLASH GENE
Symbol UBQLN3 contributors: SGE - updated : 04-05-2009
HGNC name ubiquilin 3
HGNC id 12510
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ubiquitin-like domain in the N terminal region
  • two 93 AAs NP with five Asn-Pro motifs
  • a C terminal ubiquitin-associated (UBA) domains
  • HOMOLOGY
    interspecies homolog to murine Plic2
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • regulation of cell cycle progression during spermatogenesis
  • regulating cell survival during starvation
  • protects cells against starvation-induced cell death propagated by overexpression of mutant Alzheimer disease PS2N141I protein
  • a possible function of ubiquilin might be to bind and transport ubiquitinated proteins to autophagosomes
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • testis-specific cyclin A1 (CCNA1)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS