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FLASH GENE
Symbol UBL4A contributors: mct - updated : 30-12-2015
HGNC name ubiquitin-like 4A
HGNC id 12505
Location Xq28      Physical location : 153.712.057 - 153.714.932
Synonym name
  • ubiquitin-like 4
  • G6PD/ubiquitin related sequence
    • Synonym symbol(s) GDX, DXS254E, UBLG, UBL4, DX254E, G6PD, GET5, MDY2, TMA24
    DNA
    TYPE like-sequence
    STRUCTURE 2.95 kb     4 Exon(s)
    regulatory sequence cytosine-phosphate-guanine/HTF
    MAPPING cloned   linked   status confirmed
    Map cen - UBL4A - DXS253E - G6PD - qter
    Authors Sedlacek (93)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2395 17 157 - 2007 16872915
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis    Mus musculus
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivesperm cell Mus musculus
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal region of homology with ubiquitin
  • an ubiquitin-like domain , and UBL domains from UBL4A and BAG6 directly compete for binding to SGTA at the same site
  • a region of homology with the C terminal hormonogenic site of tyroglobulin in the central part of its (UBL4) C terminal region
    • HOMOLOGY
    interspecies homolog to C.elegans r13f6.1
    intraspecies homolog to G6PD/ubiquitin related sequence
    Homologene
    FAMILY
  • ubiquitin family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • GET4 and UBL4A are found mainly in cytoplasm
  • UBL4A and GET4 translocate to the nucleus upon DNA damage and appear to play redundant roles in cell killing, as depletion of either one has no effect but co-depletion leads to resistance
    • basic FUNCTION
  • specific role in vital functions of the cell
  • instead of targeting UBL4A for degradation, polyubiquitination is associated with irreversible proteolytic processing and inactivation of BAG6
  • converts isoform TC45 of PTPN2, a nonspecific phosphatase, into a STAT3-specific phosphatase by bridging an association between TC45 and STAT3
  • role for GET4/UBL4A in recycling ASNA1 from the ER membrane at the end of the targeting reaction
  • is required for insulin-induced AKT1 plasma membrane translocation through promotion of Arp2/3-dependent actin branching
    • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterotrimeric BAG6 complex, which also includes UBL4A and transmembrane domain recognition complex 35 (GET4)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SGTA can bind either BAG6, or UBL4A, but not both at the same time
  • ERAD E3 AMFR can ubiquitinate not only ERAD substrates, but also the machinery protein UBL4A, a key component of the BAG6 chaperone complex
  • USP13 is a AMFR-associated DUB that eliminates ubiquitin conjugates from UBL4A to maintain the functionality of BAG6
  • UBL4A promotes STAT3 dephosphorylation via mediating the interaction between TC45 (the nuclear isoform of PTPN2) and STAT3 specifically
  • tight association of BAG6 and UBL4a resulted in modulation of UBL4a protein stability in cells
  • directly interacts with Arp2/3 to accelerate actin branching and networking
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS