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Symbol TUBB8 contributors: mct - updated : 18-10-2017
HGNC name tubulin beta 8 class VIII
HGNC id 20773
Corresponding disease
OOMD2 oocyte maturation defect 2
Location 10p15.3      Physical location : 92.827 - 95.504
Synonym name
  • HSA10p15 beta-tubulin 4Q
  • Synonym symbol(s) OOMD, OOMD2, bA631M21.2
    DNA
    TYPE functioning gene
    STRUCTURE 3.07 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1504 - 444 - 2016 26789871
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemovary    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductiveoocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    basic FUNCTION
  • is a primate-specific beta-tubulin isotype whose expression is confined to oocytes and the early embryo
  • important role of TUBB8 in oocyte maturation, fertilization and early embryonic developmen
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) OOMD2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    mutations occur in a high proportion of infertile women with oocyte maturation arrest
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS