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FLASH GENE
Symbol TUBB8 contributors: mct - updated : 18-10-2017
HGNC name tubulin beta 8 class VIII
HGNC id 20773
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY structural protein
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
basic FUNCTION
  • is a primate-specific beta-tubulin isotype whose expression is confined to oocytes and the early embryo
  • important role of TUBB8 in oocyte maturation, fertilization and early embryonic developmen
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) OOMD2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    mutations occur in a high proportion of infertile women with oocyte maturation arrest
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS