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FLASH GENE
Symbol TUBB8 contributors: mct - updated : 18-10-2017
HGNC name tubulin beta 8 class VIII
HGNC id 20773
DNA
TYPE functioning gene
STRUCTURE 3.07 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1504 - 444 - 2016 26789871
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovary    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductiveoocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY structural protein
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
basic FUNCTION
  • is a primate-specific beta-tubulin isotype whose expression is confined to oocytes and the early embryo
  • important role of TUBB8 in oocyte maturation, fertilization and early embryonic developmen
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) OOMD2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    mutations occur in a high proportion of infertile women with oocyte maturation arrest
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS