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FLASH GENE
Symbol TSG1C contributors: npt - updated : 14-12-2009
Location 1p36.3-p32.2      Physical location : -
Genatlas name tumor suppressor gene(s),chromosome 1
DNA
TYPE functioning gene
MAPPING cloned   linked   status confirmed
Map pter - D1S243 - D1S80 - D1S468 - D1S47 - D1S214 - [D1S160 - D1S450 ,D1S244 - D1S503 - TNFRSF1B - NPPA ,D1S434 - PRDM2 - D1S489 - D1S228 - D1S2672 - D1S2728 - D1S507 - D1S436 - D1S170 - PAX7 - D1S199 - ALPL - D1S478 ] - D1S234 - (D1S247 - D1S470 - D1S513 - D1S233 ) - D1S201 - D1S472 - D1S496 - cen
Authors Caron (95), Yeh (95), Casciano (96), Hilgers (99), Chadwick (00)
Text [frequent location in the region of LOH ], (LOH in pancreatic cancer)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
Homologene
FAMILY
CATEGORY tumor suppressor
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • tumor suppressor gene(s)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in breast cancer, pancreatic cancer, oligodendroglial, gastric, in yolk sac tumor cancer, neuroblastoma, intestinal tumor, colorectal cancer
    tumoral   LOH    
    in solid tumor, breast cancer, ovarian cancer, neuroblastoma, hepatocellular carcinoma, gastric carcinoma, colon carcinoma, Wilms tumor
    tumoral germinal mutation      
    in colorectal tumor
    tumoral   amplification    
    duplicated in neuroblastoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS