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FLASH GENE
Symbol PRDM2 contributors: mct - updated : 31-03-2008
HGNC name PR domain containing 2, with ZNF domain
HGNC id 9347
Location 1p36.21      Physical location : 14.026.734 - 14.151.572
Synonym name
  • retinoblastoma RB1 protein interacting zinc finger RIZ
  • positive regulatory domain family protein 2
  • GATA-3 binding protein G3B
  • MTE-binding protein
  • zinc-finger DNA-binding protein
  • lysine N-methyltransferase 8
  • Synonym symbol(s) RIZ, RIZ1, RIZ2, HUMHOXY1, MTB-ZF, KMT8
    EC.number 2.1.1.43
    DNA
    TYPE functioning gene
    STRUCTURE 124.84 kb     10 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site   HRE
    motif
    text structure RB binding motif
    MAPPING cloned Y linked N status confirmed
    Map see TSG1C
    Physical map
    TNFRSF8 1p36 tumor necrosis factor receptor superfamily, member 8 TNFRSF1B 1p36.32 tumor necrosis factor receptor superfamily, member 1B LOC390998 1 similar to 60S ribosomal protein L10 (QM protein) (Tumor suppressor QM) (Laminin receptor homolog) FLJ10619 DHRS3 1p36.1 dehydrogenase/reductase (SDR family) member 3 LOC343066 1p36.21 similar to Arylacetamide deacetylase (AADAC) LOC126767 1p36.21 similar to arylacetamide deacetylase MGC35194 1p36.21 hypothetical protein MGC35194 LOC390999 1 similar to Hypothetical protein DJ1198H6.2 LOC65121 1p36.21 hypothetical protein similar to preferentially expressed antigen of melanoma LOC343068 1p36.21 hypothetical protein LOC343068 LOC391000 1 similar to Hypothetical protein DJ845O24.1 LOC343069 1p36.21 similar to Heterogeneous nuclear ribonucleoprotein C-like dJ845O24.4 (hnRNP core protein C-like) LOC65122 1p36.21 hypothetical protein similar to preferentially expressed antigen of melanoma LOC343070 1p36.21 hypothetical protein LOC343070 LOC391001 1 similar to Hypothetical protein DJ845O24.2 LOC339553 1p36.21 similar to hypothetical protein LOC374947 1p36.21 similar to Hypothetical protein DJ845O24.2 LOC343071 1p36.21 hypothetical protein LOC343071 LOC391002 1 similar to Hypothetical protein DJ1198H6.2 LOC374949 1p36.21 similar to Hypothetical protein DJ845O24.1 LOC374950 1p36.21 similar to Hypothetical protein DJ845O24.2 LOC339545 1p36.21 similar to hypothetical protein LOC391003 1 similar to hypothetical protein LOC391004 1 similar to Hypothetical protein DJ845O24.2 LOC126755 1p36.21 hypothetical protein LOC126755 LOC388594 1 similar to WD repeat domain 9 isoform A; WD repeat domain 9; cAMP response element binding and beta-tranducin family-like; transcriptional unit N143 T1A-2 1p36 lung type-I cell membrane-associated glycoprotein PRDM2 1p36.1 PR domain containing 2, with ZNF domain LOC391005 1 similar to KIAA1026 protein LOC391006 1 similar to beta-tubulin cofactor A KIAA1026 1p36.13 KIAA1026 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 7970 - 1718 - 2008 18488713
  • contains the PR (PRDI-BF1 and RIZ homologous) domain
  • having multiple zinc finger motifs that recognize specific DNA sequences
  • candidate tumour suppressor
  • commonly silenced in many types of tumors
  • 4 initiation site 6206 162 1481 normally in breast cancer 2008 18082620
  • also called RIZ2 (MTBZF), or variant 3/isoform c
  • lacking a N terminal motif
  • enhancement of its expression may have an important role in leukaemogenesis
  • 9 - 7466 - 1682 - 2008 18037365
    8 - 2715 - 226 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Connectivebone  highly
    Muscularstriatumskeletal highly
    cell lineage retinoblastoma cells
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a PR/SET motif at its N-terminus (AA 30
  • 140)
  • eight zinc finger motifs
  • Krüppel-like with the PRD domain (PRD1-BF1-RIZ1), lacking in RIZ2, leucine zipper, GTPase, SH3 and pRB domains
  • a PR binding domain in the C terminal region, flexible, similar to SET domains, mediating interactions or oligomerization, and involved in methylation of H3
  • a SET domain
  • HOMOLOGY
    interspecies homolog to murine Prdm2
    Homologene
    FAMILY
  • nuclear histone/ protein methyltransferase superfamily
  • PR-domain protein family
  • CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • histone methyltransferase, acting as a putative tumor suppressor
  • transcriptional regulation during neuronal differentiation
  • involved in B cell differentiation and the development of B cell lymphomas
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • RIZ interacting
  • associate with promoter regions of IGF1 and increase histone H3 lysine 9 methylation (may contribute to potential CML tumor suppressor properties of PRDM2
  • interacting with YY1 (coexpression of PRDM2/YY1 proteins suggests a tandem regulatory mechanism in human osteosarcoma cells and tissues)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in acute lymphoblastic leukemia
    tumoral       loss of function
    by DNA methylation in liver and breast and stomach cancer
    tumoral   LOH    
    in pheochromocytomas and paragangliomas
    tumoral       loss of function
    in pheochromocytomas and paragangliomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    therapeutic potential of inhibiting IGF1 pathway in the acute phase of CML (chronic myelogenous leukemia)
    ANIMAL & CELL MODELS