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FLASH GENE
Symbol TSEN2 contributors: mct/npt - updated : 26-03-2007
HGNC name tRNA splicing endonuclease 2 homolog (S. cerevisiae)
HGNC id 28422
Corresponding disease
PCH2B pontocerebellar hypoplasia 2B
Location 3p25.1      Physical location : 12.525.930 - 12.574.819
Synonym name
  • tRNA splicing endonuclease 2
  • tRNA-intron endonuclease Sen2
  • Synonym symbol(s) MGC2776, HSEN2, SEN2, SEN2L, MGC4440
    EC.number 3.1.27.9
    DNA
    TYPE functioning gene
    STRUCTURE 48.78 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2150 - 465 - -
    11 - 2023 - 439 - -
    13 - 1941 - 406 - -
    9 - 2697
    12 - 2402 - 465 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbraincerebellumcerebellar cortex 
    Visualeyeretina   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • catalytic C-terminal domain
  • HOMOLOGY
    interspecies homolog to murine Tsen2
    Homologene
    FAMILY
  • tRNA-intron endonuclease family
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • requiring for cell growth and division, catalyzing the removal of introns, the first step in tRNA splicing
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PCH2B
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS