Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TRRAP contributors: mct/pgu - updated : 02-12-2011
HGNC name transformation/transcription domain-associated protein
HGNC id 12347
Location 7q22.1      Physical location : 98.476.112 - 98.610.864
Synonym name
  • TIP60-containing histone acetyltransferase(HAT) complex
  • 350/400 kDa PCAF-associated factor
  • Synonym symbol(s) FLJ10671, PAF400, TR-AP, PAF350/400, STAF40, Tra1
    DNA
    TYPE functioning gene
    STRUCTURE 134.75 kb     71 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    KPI2 7q22.1 zinc finger protein 95 homolog (mouse) MIST1 7q22.1 class II bHLH protein MIST1 DKFZP434B0335 7q22.1 DKFZP434B0335 protein BRI3 7q22.1 brain protein I3 LOC55971 7q22.1 insulin receptor tyrosine kinase substrate NPTX2 7q21.3-q22.1 neuronal pentraxin II DKFZp761L1417 7q22.1 hypothetical protein DKFZp761L1417 TRRAP 7q21.3-q22.1 transformation/transcription domain-associated protein SMURF1 7q21.1-q31.1 transformation/transcription domain-associated protein LOC389539 7 similar to importin alpha 1b ARPC1A 7q22.1-q31.33 actin related protein 2/3 complex, subunit 1A, 41kDa ARPC1B 7q22.1-q31.33 actin related protein 2/3 complex, subunit 1B, 41kDa PDAP1 7q11.21 PDGFA associated protein 1 G10 7q11.21 PDGFA associated protein 1 CPSF4 7q22.1 cleavage and polyadenylation specific factor 4, 30kDa KIAA0632 7q22.1 cleavage and polyadenylation specific factor 4, 30kDa ATP5J2 7q21.3-q22 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit f, isoform 2 LOC285989 7q22.1 hypothetical protein LOC285989 ZNF394 7q22.1 zinc finger protein 394 ZFP95 7q22 zinc finger protein 95 homolog (mouse)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    59 - 12596 - 3830 - 1998 9708738
    - - 12695 - 3859 - 1998 9708738
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
     liver    
     mouthtongue  highly
    Lymphoid/Immunethymus     Homo sapiens
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C terminal domain exhibiting a striking homology to the PI-3 kinase (phosphatidyl inositol-3 kinase, catalytic family)
  • a FAT domain
  • a FATC domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • transformation/transcription domain associated protein
  • essential cofactor for the c-Myc and E2F oncoproteins
  • may be required for the mitotic checkpoint and normal cell cycle progression
  • functions as part of a multiprotein coactivator complex possessing histone acetyltranferase activity that is central to the transcriptional activity of TP53, MYC and E2F1
  • plays a central role in myc (c-myc) transcription activation, and also participates in cell transformation by myc
  • appears to be responsible for the recruitment of these complexes to chromatin during transcription, replication and DNA repair
  • required with GCN5L2 for c-Myc to promote cell growth and transformation
  • INTS1, TRRAP, and SKIV2L2 are implicated in distinct steps of thymus development
  • role for the histone acetytransferase cofactor TRRAP in the maintenance of hematopietic stem/progenitor cells
  • critical role for TRRAP in the mechanism that maintains hematopoietic stem cells and hematopoietic system
  • critical role for TRRAP in maintaining a tumorigenic, stem cell-like state
  • may function as an oncogene
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the Tip60 complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with KAT5 associate with histone gene promoters at the G(1)/S-phase boundary in an NPAT-dependent manner
  • interacts with Skp1/SCF and mediates its recruitment to beta-catenin target promoter in chromatin
  • ANKRD37 functions as an E3 ubiquitin ligase substrate recognition subunit to target TRRAP for ubiquitylation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to melanoma
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS