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FLASH GENE
Symbol TRRAP contributors: mct/pgu - updated : 14-05-2019
HGNC name transformation/transcription domain-associated protein
HGNC id 12347
Corresponding disease
TRRAPD TRRAP deficiency
Location 7q22.1      Physical location : 98.476.112 - 98.610.864
Synonym name
  • TIP60-containing histone acetyltransferase(HAT) complex
  • 350/400 kDa PCAF-associated factor
  • Synonym symbol(s) FLJ10671, PAF400, TR-AP, PAF350/400, STAF40, Tra1
    DNA
    TYPE functioning gene
    STRUCTURE 134.75 kb     71 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    71 - 12608 - 3830 - 1998 9708738
    72 - 12695 - 3859 - 1998 9708738
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
     liver    
     mouthtongue  highly
    Lymphoid/Immunethymus     Homo sapiens
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C terminal domain exhibiting a striking homology to the PI-3 kinase (phosphatidyl inositol-3 kinase, catalytic family)
  • a FAT domain
  • a FATC domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • transformation/transcription domain associated protein
  • essential cofactor for the c-Myc and E2F oncoproteins
  • may be required for the mitotic checkpoint and normal cell cycle progression
  • functions as part of a multiprotein coactivator complex possessing histone acetyltranferase activity that is central to the transcriptional activity of TP53, MYC and E2F1
  • plays a central role in myc (c-myc) transcription activation, and also participates in cell transformation by myc
  • appears to be responsible for the recruitment of these complexes to chromatin during transcription, replication and DNA repair
  • required with GCN5L2 for c-Myc to promote cell growth and transformation
  • INTS1, TRRAP, and SKIV2L2 are implicated in distinct steps of thymus development
  • role for the histone acetytransferase cofactor TRRAP in the maintenance of hematopietic stem/progenitor cells
  • critical role for TRRAP in the mechanism that maintains hematopoietic stem cells and hematopoietic system
  • critical role for TRRAP in maintaining a tumorigenic, stem cell-like state
  • may function as an oncogene
  • chromatin modifier TRRAP is targeted for destruction in a cell cycle-dependent fashion
  • TRRAP is a critical part of the mechanism that restricts differentiation and promotes the maintenance of key features of ESCs
  • critical function of TRRAP in cell proliferation
  • essential component of multiple histone acetyltransferase complexes,that is a central regulator of multiciliated cell (MCC) formation
  • is an adaptor protein and a component of histone acetyltransferase complex
  • TRRAP plays likely an important role in the regulation of the proliferation and stemness of ovarian cancer stem cells
  • multidomain protein kinase that works as a genetic cofactor to influence DNA methylation patterns, DNA damage repair, and chromatin remodeling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the Tip60 complex
  • common component of many histone acetyltransferase (HAT) complexes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with KAT5 associate with histone gene promoters at the G(1)/S-phase boundary in an NPAT-dependent manner
  • interacts with Skp1/SCF and mediates its recruitment to beta-catenin target promoter in chromatin
  • ANKRD37 functions as an E3 ubiquitin ligase substrate recognition subunit to target TRRAP for ubiquitylation
  • MYC interacts with the human STAGA coactivator complex via multivalent contacts with the KAT2A and TRRAP subunits
  • physically interact and co-localize with USP7
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) TRRAPD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    impairs B-cell development but does not directly affect class switch recombination (CSR)
    Susceptibility to melanoma
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS