basic FUNCTION
| transformation/transcription domain associated protein |
|
essential cofactor for the c-Myc and E2F oncoproteins |
|
may be required for the mitotic checkpoint and normal cell cycle progression |
|
functions as part of a multiprotein coactivator complex possessing histone acetyltranferase activity that is central to the transcriptional activity of TP53, MYC and E2F1 |
|
plays a central role in myc (c-myc) transcription activation, and also participates in cell transformation by myc |
|
appears to be responsible for the recruitment of these complexes to chromatin during transcription, replication and DNA repair |
|
required with GCN5L2 for c-Myc to promote cell growth and transformation |
|
INTS1, TRRAP, and SKIV2L2 are implicated in distinct steps of thymus development |
|
role for the histone acetytransferase cofactor TRRAP in the maintenance of hematopietic stem/progenitor cells |
|
critical role for TRRAP in the mechanism that maintains hematopoietic stem cells and hematopoietic system |
|
critical role for TRRAP in maintaining a tumorigenic, stem cell-like state |
|
may function as an oncogene |
|
chromatin modifier TRRAP is targeted for destruction in a cell cycle-dependent fashion |
|
TRRAP is a critical part of the mechanism that restricts differentiation and promotes the maintenance of key features of ESCs |
|
critical function of TRRAP in cell proliferation |
|
essential component of multiple histone acetyltransferase complexes,that is a central regulator of multiciliated cell (MCC) formation |
|
is an adaptor protein and a component of histone acetyltransferase complex |
|
TRRAP plays likely an important role in the regulation of the proliferation and stemness of ovarian cancer stem cells |
|
multidomain protein kinase that works as a genetic cofactor to influence DNA methylation patterns, DNA damage repair, and chromatin remodeling |