Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

TRRAP

contributors: mct/pgu - updated : 14-05-2019

HGNC name	transformation/transcription domain-associated protein
HGNC id	12347

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly   liver           mouth tongue     highly Lymphoid/Immune thymus         Homo sapiens Respiratory respiratory tract larynx     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	C terminal domain exhibiting a striking homology to the PI-3 kinase (phosphatidyl inositol-3 kinase, catalytic family)
	a FAT domain
	a FATC domain

HOMOLOGY

Homologene

FAMILY

CATEGORY

protooncogene

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,organelle,Golgi
	intracellular,nucleus,nucleoplasm

basic FUNCTION	transformation/transcription domain associated protein
	essential cofactor for the c-Myc and E2F oncoproteins
	may be required for the mitotic checkpoint and normal cell cycle progression
	functions as part of a multiprotein coactivator complex possessing histone acetyltranferase activity that is central to the transcriptional activity of TP53, MYC and E2F1
	plays a central role in myc (c-myc) transcription activation, and also participates in cell transformation by myc
	appears to be responsible for the recruitment of these complexes to chromatin during transcription, replication and DNA repair
	required with GCN5L2 for c-Myc to promote cell growth and transformation
	INTS1, TRRAP, and SKIV2L2 are implicated in distinct steps of thymus development
	role for the histone acetytransferase cofactor TRRAP in the maintenance of hematopietic stem/progenitor cells
	critical role for TRRAP in the mechanism that maintains hematopoietic stem cells and hematopoietic system
	critical role for TRRAP in maintaining a tumorigenic, stem cell-like state
	may function as an oncogene
	chromatin modifier TRRAP is targeted for destruction in a cell cycle-dependent fashion
	TRRAP is a critical part of the mechanism that restricts differentiation and promotes the maintenance of key features of ESCs
	critical function of TRRAP in cell proliferation
	essential component of multiple histone acetyltransferase complexes,that is a central regulator of multiciliated cell (MCC) formation
	is an adaptor protein and a component of histone acetyltransferase complex
	TRRAP plays likely an important role in the regulation of the proliferation and stemness of ovarian cancer stem cells
	multidomain protein kinase that works as a genetic cofactor to influence DNA methylation patterns, DNA damage repair, and chromatin remodeling

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	component of the Tip60 complex
	common component of many histone acetyltransferase (HAT) complexes

INTERACTION

DNA

RNA

small molecule

protein	with KAT5 associate with histone gene promoters at the G(1)/S-phase boundary in an NPAT-dependent manner
	interacts with Skp1/SCF and mediates its recruitment to beta-catenin target promoter in chromatin
	ANKRD37 functions as an E3 ubiquitin ligase substrate recognition subunit to target TRRAP for ubiquitylation
	MYC interacts with the human STAGA coactivator complex via multivalent contacts with the KAT2A and TRRAP subunits
	physically interact and co-localize with USP7

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

TRRAPD

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function impairs B-cell development but does not directly affect class switch recombination (CSR)

Susceptibility

to melanoma

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS