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FLASH GENE
Symbol TPR contributors: mct - updated : 01-06-2018
HGNC name translocated promoter region (to activated MET oncogene)
HGNC id 12017
Location 1q25.3      Physical location : 186.280.787 - 186.344.457
Synonym name
  • megator
  • nuclear pore complex-associated protein TPR
  • translocated promoter region protein
  • DNA
    TYPE functioning gene
    STRUCTURE 63.67 kb     51 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    RGS16 1q25-q31 regulator of G-protein signalling 16 RGS8 1q25-q31 regulator of G-protein signalling 8 NPL 1q25 N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) DHX9 1q25 DEAH (Asp-Glu-Ala-His) box polypeptide 9 C1orf14 1q25-q31 chromosome 1 open reading frame 14 LOC391143 1 similar to natural cytotoxicity triggering receptor 1; lymphocyte antigen 94 (mouse) homolog (activating NK-receptor; NK-p46); lymphocyte antigen 94 (mouse) homolog (activating NK-receptor ; NK-p46); lymphocyte antigen 94 homolog, a LOC343326 1q25.2 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) LAMC1 1q31 laminin, gamma 1 (formerly LAMB2) LAMC2 1q25-q31 laminin, gamma 2 NMNAT2 1q25-q31 nicotinamide nucleotide adenylyltransferase 2 C1orf16 1q25-q31 chromosome 1 open reading frame 16 NCF2 1q25 neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2) ARPC5 1q25.2 actin related protein 2/3 complex, subunit 5, 16kDa RGL 1q25.2 actin related protein 2/3 complex, subunit 5, 16kDa C1orf17 1q25-q31 chromosome 1 open reading frame 17 C1orf19 1q25-q31 chromosome 1 open reading frame 19 LOC391144 1 similar to Rho-GTPase-activating protein 8 C1orf21 1q25-q31 chromosome 1 open reading frame 21 C1orf22 1q24-q25 chromosome 1 open reading frame 22 C1orf24 1q25-q31 chromosome 1 open reading frame 24 RNF2 1q25.1 ring finger protein 2 C1orf25 1q25.2 chromosome 1 open reading frame 25 C1orf26 1q25 chromosome 1 open reading frame 26 IVNS1ABP 1q25.1-q31.1 influenza virus NS1A binding protein FIBL-6 1q25.3 hemicentin PRG4 1q25-q31 proteoglycan 4, (megakaryocyte stimulating factor, articular superficial zone protein, camptodactyly, arthropathy, coxa vara, pericarditis syndrome) TPR 1q25 translocated promoter region (to activated MET oncogene) C1orf27 1q25-q31 translocated promoter region (to activated MET oncogene) PDC 1q32-q41 phosducin LOC391145 1 similar to KIAA1871 protein PTGS2 1q25.2-q25.3 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) PLA2G4A 1q25 phospholipase A2, group IVA (cytosolic, calcium-dependent) LOC343332 1q25.3 similar to Farnesyl pyrophosphate synthetase (FPP synthetase) (FPS) (Farnesyl diphosphate synthetase)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    51 - 9727 - 2363 - 2017 28528776
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebonesubchondral  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    coiled- coil protein with an acidic Cter domain
    secondary structure
  • TPR(2-142) contains a continuous 124-AA alpha helix that forms an antiparallel tetramer from two leucine zipper-containing parallel coiled coils
  • HOMOLOGY
    interspecies homolog to drosophila Megator
    Homologene
    FAMILY Ezrin/radixin/moesin family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,kinetochore
    intracellular,nuclear envelope,pore
    basic FUNCTION
  • component of the cytoplasmic fibrils of the nuclear pore complex implicated in nuclear protein import
  • TPR, and the spindle assembly checkpoint (SAC) protein MAD2L1 form a conserved complex that localizes to a nuclear derived spindle matrix in living cells
  • is a kinetochore-independent, rate-limiting factor required to mount and sustain a robust spindle assembly checkpoint (SAC) response
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with HD (role in the nuclear export of N-terminal HD)
  • TPR plays an important role in quality control of mRNA trafficked on the NXF1 pathway
  • plays a role in autophagy through controlling HSPA4 and HSF1 mRNA export, TP53 trafficking with karyopherin CRM1, and potentially through direct transcriptional regulation of autophagy factors
  • TPR import was mediated by the most abundant import receptor, KPNA2, which binds the bipartite NLS in TPR with nanomolar affinity
  • LMNA inhibited TPR import because transport of large protein cargoes was sensitive to changes in the Ran nuclear/cytoplasmic distribution that occurred in PRO1
  • TPR is required for normal SAC response by stabilizing MAD1L1 and MAD2L2 before mitosis
  • SLK interacts with TPR and ACTN4 in cells, and these protein-protein interactions may control the subcellular localization and the biological activity of SLK
  • TPR is a novel AKAP8 binding partner
  • cell & other
    REGULATION
    Other is phosphorylated in both a MAP-kinase-dependent and MAP-kinase-independent manner, and TPR acts as both a substrate and as a scaffold for MAPK1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    and several rearrangements (TPR-MET;TPR-TRKA (NTRK1),in papillary thyroid carcinoma
    tumoral fusion      
    fusion FGFR1/TPR in 8p11 myeloproliferative syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS