Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TPR contributors: mct - updated : 01-06-2018
HGNC name translocated promoter region (to activated MET oncogene)
HGNC id 12017
DNA
TYPE functioning gene
STRUCTURE 63.67 kb     51 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
51 - 9727 - 2363 - 2017 28528776
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebonesubchondral  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
coiled- coil protein with an acidic Cter domain
secondary structure
  • TPR(2-142) contains a continuous 124-AA alpha helix that forms an antiparallel tetramer from two leucine zipper-containing parallel coiled coils
    • HOMOLOGY
    interspecies homolog to drosophila Megator
    Homologene
    FAMILY Ezrin/radixin/moesin family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,kinetochore
    intracellular,nuclear envelope,pore
    basic FUNCTION
  • component of the cytoplasmic fibrils of the nuclear pore complex implicated in nuclear protein import
  • TPR, and the spindle assembly checkpoint (SAC) protein MAD2L1 form a conserved complex that localizes to a nuclear derived spindle matrix in living cells
  • is a kinetochore-independent, rate-limiting factor required to mount and sustain a robust spindle assembly checkpoint (SAC) response
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with HD (role in the nuclear export of N-terminal HD)
  • TPR plays an important role in quality control of mRNA trafficked on the NXF1 pathway
  • plays a role in autophagy through controlling HSPA4 and HSF1 mRNA export, TP53 trafficking with karyopherin CRM1, and potentially through direct transcriptional regulation of autophagy factors
  • TPR import was mediated by the most abundant import receptor, KPNA2, which binds the bipartite NLS in TPR with nanomolar affinity
  • LMNA inhibited TPR import because transport of large protein cargoes was sensitive to changes in the Ran nuclear/cytoplasmic distribution that occurred in PRO1
  • TPR is required for normal SAC response by stabilizing MAD1L1 and MAD2L2 before mitosis
  • two additional interaction sites between TPR and SNUPN, suggesting a possible role for TPR import into the nucleus
  • SLK interacts with TPR and ACTN4 in cells, and these protein-protein interactions may control the subcellular localization and the biological activity of SLK
  • TPR is a novel AKAP8 binding partner
    • cell & other
    REGULATION
    Other is phosphorylated in both a MAP-kinase-dependent and MAP-kinase-independent manner, and TPR acts as both a substrate and as a scaffold for MAPK1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    and several rearrangements (TPR-MET;TPR-TRKA (NTRK1),in papillary thyroid carcinoma
    tumoral fusion      
    fusion FGFR1/TPR in 8p11 myeloproliferative syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS