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FLASH GENE
Symbol TPR contributors: mct - updated : 01-06-2018
HGNC name translocated promoter region (to activated MET oncogene)
HGNC id 12017
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
coiled- coil protein with an acidic Cter domain
secondary structure
  • TPR(2-142) contains a continuous 124-AA alpha helix that forms an antiparallel tetramer from two leucine zipper-containing parallel coiled coils
    • HOMOLOGY
    interspecies homolog to drosophila Megator
    Homologene
    FAMILY Ezrin/radixin/moesin family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,kinetochore
    intracellular,nuclear envelope,pore
    basic FUNCTION
  • component of the cytoplasmic fibrils of the nuclear pore complex implicated in nuclear protein import
  • TPR, and the spindle assembly checkpoint (SAC) protein MAD2L1 form a conserved complex that localizes to a nuclear derived spindle matrix in living cells
  • is a kinetochore-independent, rate-limiting factor required to mount and sustain a robust spindle assembly checkpoint (SAC) response
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with HD (role in the nuclear export of N-terminal HD)
  • TPR plays an important role in quality control of mRNA trafficked on the NXF1 pathway
  • plays a role in autophagy through controlling HSPA4 and HSF1 mRNA export, TP53 trafficking with karyopherin CRM1, and potentially through direct transcriptional regulation of autophagy factors
  • TPR import was mediated by the most abundant import receptor, KPNA2, which binds the bipartite NLS in TPR with nanomolar affinity
  • LMNA inhibited TPR import because transport of large protein cargoes was sensitive to changes in the Ran nuclear/cytoplasmic distribution that occurred in PRO1
  • TPR is required for normal SAC response by stabilizing MAD1L1 and MAD2L2 before mitosis
  • two additional interaction sites between TPR and SNUPN, suggesting a possible role for TPR import into the nucleus
  • SLK interacts with TPR and ACTN4 in cells, and these protein-protein interactions may control the subcellular localization and the biological activity of SLK
  • TPR is a novel AKAP8 binding partner
    • cell & other
    REGULATION
    Other is phosphorylated in both a MAP-kinase-dependent and MAP-kinase-independent manner, and TPR acts as both a substrate and as a scaffold for MAPK1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    and several rearrangements (TPR-MET;TPR-TRKA (NTRK1),in papillary thyroid carcinoma
    tumoral fusion      
    fusion FGFR1/TPR in 8p11 myeloproliferative syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS