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FLASH GENE
Symbol TPP2 contributors: mct - updated : 10-04-2018
HGNC name tripeptidyl peptidase II
HGNC id 12016
Location 13q33.1      Physical location : 103.249.285 - 103.331.521
Synonym name tripeptidyl aminopeptidase
Synonym symbol(s) FLJ40359, TPP-II, TPP-2
EC.number 3.4.14.10
DNA
TYPE functioning gene
STRUCTURE 82.24 kb     29 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter (CAAT box)
cytosine-phosphate-guanine/HTF
Binding site   transcription factor
text structure
  • promoter could be localized to a 215 bp fragment upstream of the initiation codon
  • region GC-rich, lacking a TATA-box and containing two inverted CCAAT-boxes and a E-box
  • USF-1 (upstream stimulatory factor-1) binds to the E-box in the promoter
  • MAPPING cloned Y linked   status provisional
    Physical map
    DOCK9 13q32.1 dedicator of cytokinesis 9 LOC390421 13 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) PHGDHL1 13 phosphoglycerate dehydrogenase like 1 GPR18 13q32 G protein-coupled receptor 18 EBI2 13q32.3 Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor) LOC390422 13 similar to Epstein-Barr virus induced gene 2 TM9SF2 13q32.2 transmembrane 9 superfamily member 2 CLYBL 13q32.3 citrate lyase beta like ZIC5 13q32.2 Zic family member 5 (odd-paired homolog, Drosophila) ZIC2 13q32 Zic family member 2 (odd-paired homolog, Drosophila) PCCA 13q32 propionyl Coenzyme A carboxylase, alpha polypeptide LOC87769 13q32.3 hypothetical protein BC004360 FLJ14624 13q32.3 hypothetical protein FLJ14624 LOC390423 13 similar to ADP-ribosylation factor 4 VGCNL1 13q32.3 voltage gated channel like 1 ITGBL1 13q33 integrin, beta-like 1 (with EGF-like repeat domains) FGF14 13q34 fibroblast growth factor 14 TPP2 13q32-q33 tripeptidyl peptidase II LOC196541 13q33.1 similar to RIKEN cDNA 2310038H17 FLJ40176 13q33.1 hypothetical protein FLJ40176 LOC93081 13q33.1 hypothetical protein BC015148 KDELC1 13q33 KDEL (Lys-Asp-Glu-Leu) containing 1 BIVM 13q32-q33.1 basic, immunoglobulin-like variable motif containing ERCC5 13q22 excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum, complementation group G (Cockayne syndrome)) LOC121952 13q33.1 hypothetical protein LOC121952 SLC10A2 13q33 solute carrier family 10 (sodium/bile acid cotransporter family), member 2 G30 13q33.2 solute carrier family 10 (sodium/bile acid cotransporter family), member 2 DAOA LOC144920 13q33.2 hypothetical protein LOC144920
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    29 - 4716 - 1249 - 1999 9974389
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivemale systemtestis  highly
     male systemprostate   
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Connectivebone  highly
    Epithelialabsorptive excretorydigestive epithelium  
    Epithelialsecretoryglandular  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • peptidase S8 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • cytosolic Serine peptidase complex
  • translocates into the nucleus of most, but not all, tested tumor cell lines after DNA damage-induced by gamma irradiation or etoposide treatment
  • basic FUNCTION
  • involved in proteolysis and peptidolysis
  • involved in release of an N-terminal tripeptide from a polypeptide
  • has central and peripheral roles in regulating metabolism and its actions in fat-storing tissues might be an ancient function carried out in a protease-independent manner
  • important for maintaining normal cellular and systemic physiology, which may be relevant for potential therapeutic applications of TPP2 inhibitors
  • plays a role in creating and destroying MHC class I-presented peptides, but is not essential for generating most MHC class I-presented peptides
  • believed to act downstream of the 26S proteasome, cleaving tripeptides from the N termini of longer peptides, and it is implicated in numerous cellular processes
  • contributes to MAP-kinase-dependent DNA damage responses, and role in MAPK-dependent DNA damage signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    ubiquitin-proteasome pathway
    a component
  • component of the proteolytic cascade acting downstream of the 26s proteasome in the ubiquitin-proteasome pathway
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TPP2 can regulate sperm maturation by modulating intracellular Ca(2+) stores via RYR3
  • interaction of MYBBP1A with CDK2 and TPP2, to form a protein-protein interaction network
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS