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FLASH GENE

Symbol

TPP2

contributors: mct - updated : 10-04-2018

HGNC name	tripeptidyl peptidase II
HGNC id	12016

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	13q33.1      Physical location : 103.249.285 - 103.331.521
Synonym name	tripeptidyl aminopeptidase
Synonym symbol(s)	FLJ40359, TPP-II, TPP-2
EC.number	3.4.14.10

DNA

TYPE	functioning gene
STRUCTURE	82.24 kb     29 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter (CAAT box)
	cytosine-phosphate-guanine/HTF
	Binding site   transcription factor
text structure	promoter could be localized to a 215 bp fragment upstream of the initiation codon
	region GC-rich, lacking a TATA-box and containing two inverted CCAAT-boxes and a E-box
	USF-1 (upstream stimulatory factor-1) binds to the E-box in the promoter

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003291 29 - 4716 NP_003282 - 1249 - 1999 9974389

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Reproductive male system testis     highly   male system prostate       Respiratory respiratory tract trachea     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly Connective bone     highly Epithelial absorptive excretory digestive epithelium     Epithelial secretory glandular     Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

peptidase S8 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus
text	cytosolic Serine peptidase complex
	translocates into the nucleus of most, but not all, tested tumor cell lines after DNA damage-induced by gamma irradiation or etoposide treatment

basic FUNCTION	involved in proteolysis and peptidolysis
	involved in release of an N-terminal tripeptide from a polypeptide
	has central and peripheral roles in regulating metabolism and its actions in fat-storing tissues might be an ancient function carried out in a protease-independent manner
	important for maintaining normal cellular and systemic physiology, which may be relevant for potential therapeutic applications of TPP2 inhibitors
	plays a role in creating and destroying MHC class I-presented peptides, but is not essential for generating most MHC class I-presented peptides
	believed to act downstream of the 26S proteasome, cleaving tripeptides from the N termini of longer peptides, and it is implicated in numerous cellular processes
	contributes to MAP-kinase-dependent DNA damage responses, and role in MAPK-dependent DNA damage signaling

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

ubiquitin-proteasome pathway

a component

component of the proteolytic cascade acting downstream of the 26s proteasome in the ubiquitin-proteasome pathway

INTERACTION

DNA

RNA

small molecule

protein	TPP2 can regulate sperm maturation by modulating intracellular Ca(2+) stores via RYR3
	interaction of MYBBP1A with CDK2 and TPP2, to form a protein-protein interaction network

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS