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FLASH GENE
Symbol TPP2 contributors: mct - updated : 10-04-2018
HGNC name tripeptidyl peptidase II
HGNC id 12016
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivemale systemtestis  highly
 male systemprostate   
Respiratoryrespiratory tracttrachea  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Connectivebone  highly
Epithelialabsorptive excretorydigestive epithelium  
Epithelialsecretoryglandular  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • peptidase S8 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • cytosolic Serine peptidase complex
  • translocates into the nucleus of most, but not all, tested tumor cell lines after DNA damage-induced by gamma irradiation or etoposide treatment
  • basic FUNCTION
  • involved in proteolysis and peptidolysis
  • involved in release of an N-terminal tripeptide from a polypeptide
  • has central and peripheral roles in regulating metabolism and its actions in fat-storing tissues might be an ancient function carried out in a protease-independent manner
  • important for maintaining normal cellular and systemic physiology, which may be relevant for potential therapeutic applications of TPP2 inhibitors
  • plays a role in creating and destroying MHC class I-presented peptides, but is not essential for generating most MHC class I-presented peptides
  • believed to act downstream of the 26S proteasome, cleaving tripeptides from the N termini of longer peptides, and it is implicated in numerous cellular processes
  • contributes to MAP-kinase-dependent DNA damage responses, and role in MAPK-dependent DNA damage signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    ubiquitin-proteasome pathway
    a component
  • component of the proteolytic cascade acting downstream of the 26s proteasome in the ubiquitin-proteasome pathway
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TPP2 can regulate sperm maturation by modulating intracellular Ca(2+) stores via RYR3
  • interaction of MYBBP1A with CDK2 and TPP2, to form a protein-protein interaction network
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS