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FLASH GENE
Symbol TPP2 contributors: mct - updated : 10-04-2018
HGNC name tripeptidyl peptidase II
HGNC id 12016
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • peptidase S8 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • cytosolic Serine peptidase complex
  • translocates into the nucleus of most, but not all, tested tumor cell lines after DNA damage-induced by gamma irradiation or etoposide treatment
  • basic FUNCTION
  • involved in proteolysis and peptidolysis
  • involved in release of an N-terminal tripeptide from a polypeptide
  • has central and peripheral roles in regulating metabolism and its actions in fat-storing tissues might be an ancient function carried out in a protease-independent manner
  • important for maintaining normal cellular and systemic physiology, which may be relevant for potential therapeutic applications of TPP2 inhibitors
  • plays a role in creating and destroying MHC class I-presented peptides, but is not essential for generating most MHC class I-presented peptides
  • believed to act downstream of the 26S proteasome, cleaving tripeptides from the N termini of longer peptides, and it is implicated in numerous cellular processes
  • contributes to MAP-kinase-dependent DNA damage responses, and role in MAPK-dependent DNA damage signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    ubiquitin-proteasome pathway
    a component
  • component of the proteolytic cascade acting downstream of the 26s proteasome in the ubiquitin-proteasome pathway
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TPP2 can regulate sperm maturation by modulating intracellular Ca(2+) stores via RYR3
  • interaction of MYBBP1A with CDK2 and TPP2, to form a protein-protein interaction network
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS