Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | TNFRSF13C | contributors: - updated : 16-06-2007 |
HGNC name | tumor necrosis factor receptor superfamily, member 13C |
HGNC id | 17755 |
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Corresponding disease |
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Location | 22q13.2 Physical location : 42.321.035 - 42.322.821 | ||
Synonym name | |||
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Synonym symbol(s) | BAFFR, CD268, BAFF-R, MGC138235 |
DNA |
TYPE | functioning gene |
STRUCTURE | 1.79 kb 3 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | N | status | provisional |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | restricted |
constitutive of |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||
organ(s) |
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cells |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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HOMOLOGY |
Homologene |
FAMILY |
CATEGORY | receptor membrane |
SUBCELLULAR LOCALIZATION | plasma membrane |
text | type II transmembrane protein |
basic FUNCTION | specific TNFSF13C receptor required for BAFF-mediated mature B cell survival and for generating an effective T cell dependent immune response |
CELLULAR PROCESS | cell life, antiapoptosis |
PHYSIOLOGICAL PROCESS | immunity/defense |
PATHWAY |
metabolism |
signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule |
protein |
cell & other |
REGULATION |
ASSOCIATED DISORDERS |
corresponding disease(s) | CVID4 |
Other morbid association(s) |
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Susceptibility | to systemic lupus erythematosis (SLE) |
Variant & Polymorphism
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Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |
disrupted in A/WySnJ mice (BAFF deficient phenotype) |