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FLASH GENE
Symbol TNFRSF13C contributors: - updated : 16-06-2007
HGNC name tumor necrosis factor receptor superfamily, member 13C
HGNC id 17755
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
 thymus   lowly
Lymphoid/Immunelymph node    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • cysteine rich domain with four cysteine residues
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type II transmembrane protein
    basic FUNCTION specific TNFSF13C receptor required for BAFF-mediated mature B cell survival and for generating an effective T cell dependent immune response
    CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specifically binds TNFSF13B (BAFF), a protein belonging to the tumor necrosis factor (TNF) family, and involved in survival and maturation of B cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CVID4
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in B-cell lymphomas, but often absent in grade 3 follicular lymphomas and diffuse large B-cell lymphomas
    Susceptibility to systemic lupus erythematosis (SLE)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    disrupted in A/WySnJ mice (BAFF deficient phenotype)