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FLASH GENE
Symbol TNFRSF13C contributors: - updated : 16-06-2007
HGNC name tumor necrosis factor receptor superfamily, member 13C
HGNC id 17755
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 934 - 184 - -
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
 thymus   lowly
Lymphoid/Immunelymph node    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • cysteine rich domain with four cysteine residues
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type II transmembrane protein
    basic FUNCTION specific TNFSF13C receptor required for BAFF-mediated mature B cell survival and for generating an effective T cell dependent immune response
    CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specifically binds TNFSF13B (BAFF), a protein belonging to the tumor necrosis factor (TNF) family, and involved in survival and maturation of B cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CVID4
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in B-cell lymphomas, but often absent in grade 3 follicular lymphomas and diffuse large B-cell lymphomas
    Susceptibility to systemic lupus erythematosis (SLE)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    disrupted in A/WySnJ mice (BAFF deficient phenotype)