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FLASH GENE
Symbol TINAGL1 contributors: mct - updated : 23-06-2010
HGNC name tubulointerstitial nephritis antigen-like 1
HGNC id 19168
Location 1p35.2      Physical location : 32.042.085 - 32.053.285
Synonym name
  • androgen-regulated gene 1
  • oxidized-LDL responsive gene 2
  • tubulointerstitial nephritis antigen related protein
  • lipocalin 7
  • TINAG-like 1
  • glucocorticoid-inducible protein 5
  • Synonym symbol(s) LIECG3, GIS5, OLRG2, TIN-ag-RP, LCN7, P3ECSL, TINAGRP, PSEC0088, TINAGL, UNQ204/PRO230, ARG1
    DNA
    TYPE functioning gene
    STRUCTURE 11.20 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2252 52 467 - 2001 11170462
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly Homo sapiens
     vesselsaorta  highly Homo sapiens
    Reproductivefemale systemplacenta    Homo sapiens
    Urinarykidney   highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine  Homo sapiens
    Epithelialsecretoryglandularexocrine  Homo sapiens
    Muscularsmoothvessel highly Homo sapiens
    Muscularstriatumskeletal   Homo sapiens
    Muscularstriatumcardiac highly Homo sapiens
    cell lineage
    cell lines highly in colorectal adenocarcinoma cell line
    fluid/secretion
    at STAGE
    physiological period embryo, pregnancy
    Text
  • highly in placenta
  • in blastocysts, TINAGL1 expression was localized to the trophectoderm
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N terminal signal peptide (21 AAs), a 181 AAs long N-terminal domain containing two epidermal growth factor-like domains
  • two epidermal growth factor-like domains
  • a follistatin motif
  • a 265 AAs long cathepsin B-like domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Lcn7
    homolog to Drosophila Cg3074
    homolog to C.elegans F26e4.3
    ortholog to rattus Lcn7
    intraspecies homolog to TIN-ag
    Homologene
    FAMILY
  • TIN-ag-like proteins
  • peptidase C1 family
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    text extracellular matrix structural constituant
    basic FUNCTION
  • acting as a cysteine-type endopeptidase
  • matricellular protein that interacts with both structural matrix proteins and cell surface receptors
  • most likely plays a physical and physiological role in embryo development at postimplantation
  • may function during the postimplantation period, in particular, it associates with ITGA5B1 in the decidualized uterine endometrium
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text endosome transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • extraembryonic tissue-specific protein, and is a novel component of the Reichert membrane that interacts with LAMA1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS