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FLASH GENE
Symbol TINAGL1 contributors: mct - updated : 23-06-2010
HGNC name tubulointerstitial nephritis antigen-like 1
HGNC id 19168
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N terminal signal peptide (21 AAs), a 181 AAs long N-terminal domain containing two epidermal growth factor-like domains
  • two epidermal growth factor-like domains
  • a follistatin motif
  • a 265 AAs long cathepsin B-like domain
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Lcn7
    homolog to Drosophila Cg3074
    homolog to C.elegans F26e4.3
    ortholog to rattus Lcn7
    intraspecies homolog to TIN-ag
    Homologene
    FAMILY
  • TIN-ag-like proteins
  • peptidase C1 family
    • CATEGORY transport
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    text extracellular matrix structural constituant
    basic FUNCTION
  • acting as a cysteine-type endopeptidase
  • matricellular protein that interacts with both structural matrix proteins and cell surface receptors
  • most likely plays a physical and physiological role in embryo development at postimplantation
  • may function during the postimplantation period, in particular, it associates with ITGA5B1 in the decidualized uterine endometrium
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text endosome transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • extraembryonic tissue-specific protein, and is a novel component of the Reichert membrane that interacts with LAMA1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS