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FLASH GENE

Symbol

TINAGL1

contributors: mct - updated : 23-06-2010

HGNC name	tubulointerstitial nephritis antigen-like 1
HGNC id	19168

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	11.20 kb     12 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_022164 12 - 2252 NP_071447 52 467 - 2001 11170462

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Homo sapiens   vessels aorta     highly Homo sapiens Reproductive female system placenta       Homo sapiens Urinary kidney       highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Homo sapiens Epithelial secretory glandular exocrine   Homo sapiens Muscular smooth vessel   highly Homo sapiens Muscular striatum skeletal     Homo sapiens Muscular striatum cardiac   highly Homo sapiens

cell lineage
cell lines	highly in colorectal adenocarcinoma cell line
fluid/secretion

at STAGE

physiological period

embryo, pregnancy

Text	highly in placenta
	in blastocysts, TINAGL1 expression was localized to the trophectoderm

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an N terminal signal peptide (21 AAs), a 181 AAs long N-terminal domain containing two epidermal growth factor-like domains
	two epidermal growth factor-like domains
	a follistatin motif
	a 265 AAs long cathepsin B-like domain

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to murine Lcn7
	homolog to Drosophila Cg3074
	homolog to C.elegans F26e4.3
	ortholog to rattus Lcn7

intraspecies

homolog to TIN-ag

Homologene

FAMILY	TIN-ag-like proteins
	peptidase C1 family

CATEGORY

transport

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,cytosolic,vesicle
text	extracellular matrix structural constituant

basic FUNCTION	acting as a cysteine-type endopeptidase
	matricellular protein that interacts with both structural matrix proteins and cell surface receptors
	most likely plays a physical and physiological role in embryo development at postimplantation
	may function during the postimplantation period, in particular, it associates with ITGA5B1 in the decidualized uterine endometrium

CELLULAR PROCESS

protein, degradation

PHYSIOLOGICAL PROCESS

cellular trafficking transport

text	endosome transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

extraembryonic tissue-specific protein, and is a novel component of the Reichert membrane that interacts with LAMA1

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS