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FLASH GENE

Symbol

TAT

contributors: mct - updated : 14-10-2020

HGNC name	tyrosine aminotransferase
HGNC id	11573

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	TATD tyrosine aminotransferase deficiency
Location	16q22.2      Physical location : 71.600.753 - 71.610.998
Synonym name	L-tyrosine:2-oxoglutarate aminotransferase
	tyrosine aminotransferase, cytosolic
EC.number	2.6.1.5

DNA

TYPE	functioning gene
STRUCTURE	10.24 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

Map	cen - D16S14 ,D16S162 ,D16S181 ,HP HP - TAT ,D16S166 ,D16S176 ,D16S5 - CTRB1 - APRT APRT ,D16S7 - qter
Authors	Chen (91)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000353 12 - 2757 NP_000344 - 454 - 2010 20209601

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       specific Reproductive female system breast mammary gland   moderately

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , dimer

HOMOLOGY

interspecies	ortholog to rattus Tat
	ortholog to murine Tat

Homologene

FAMILY

class-I pyridoxal-phosphate-dependent aminotransferase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,cytosolic

basic FUNCTION	catalyzing the conversion of L-tyrosine into p-hydroxyphenylpyruvate
	pyridoxal phosphate-dependent enzyme that catalyzes the reversible transamination of tyrosine to p-hydrophenylpyruvate, an important step in tyrosine metabolism
	plays an important suppressive role in the development and progression of hepatocellular carcinoma
	catalyzes the transamination of tyrosine and other aromatic amino acids

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

aminoacid

signaling

	second step of the phenylalanine catabolism
	first step of the tyrosine catabolism

a component

INTERACTION

DNA

RNA

small molecule	cofactor,
	pyridoxal phosphate

protein

TAT promotes the release of CCNT1 from the 7SK RNP through direct binding to the 7SK RNA

cell & other

REGULATION

induced by

a factor of unknown nature launching the mechanism of TAT induction independently of cortisol, a classic TAT inducer

ASSOCIATED DISORDERS

corresponding disease(s)

TATD

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   LOH     in primary hepatocellular carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS