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FLASH GENE
Symbol TAT contributors: mct - updated : 14-10-2020
HGNC name tyrosine aminotransferase
HGNC id 11573
Corresponding disease
TATD tyrosine aminotransferase deficiency
Location 16q22.2      Physical location : 71.600.753 - 71.610.998
Synonym name
  • L-tyrosine:2-oxoglutarate aminotransferase
  • tyrosine aminotransferase, cytosolic
  • EC.number 2.6.1.5
    DNA
    TYPE functioning gene
    STRUCTURE 10.24 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map cen - D16S14 ,D16S162 ,D16S181 ,HP HP - TAT ,D16S166 ,D16S176 ,D16S5 - CTRB1 - APRT APRT ,D16S7 - qter
    Authors Chen (91)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2757 - 454 - 2010 20209601
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   specific
    Reproductivefemale systembreastmammary gland moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to rattus Tat
    ortholog to murine Tat
    Homologene
    FAMILY
  • class-I pyridoxal-phosphate-dependent aminotransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzing the conversion of L-tyrosine into p-hydroxyphenylpyruvate
  • pyridoxal phosphate-dependent enzyme that catalyzes the reversible transamination of tyrosine to p-hydrophenylpyruvate, an important step in tyrosine metabolism
  • plays an important suppressive role in the development and progression of hepatocellular carcinoma
  • catalyzes the transamination of tyrosine and other aromatic amino acids
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
  • second step of the phenylalanine catabolism
  • first step of the tyrosine catabolism
  • a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • pyridoxal phosphate
  • protein
  • TAT promotes the release of CCNT1 from the 7SK RNP through direct binding to the 7SK RNA
  • cell & other
    REGULATION
    induced by a factor of unknown nature launching the mechanism of TAT induction independently of cortisol, a classic TAT inducer
    ASSOCIATED DISORDERS
    corresponding disease(s) TATD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    in primary hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS