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FLASH GENE
Symbol TAT contributors: mct - updated : 14-10-2020
HGNC name tyrosine aminotransferase
HGNC id 11573
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   specific
Reproductivefemale systembreastmammary gland moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
interspecies ortholog to rattus Tat
ortholog to murine Tat
Homologene
FAMILY
  • class-I pyridoxal-phosphate-dependent aminotransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzing the conversion of L-tyrosine into p-hydroxyphenylpyruvate
  • pyridoxal phosphate-dependent enzyme that catalyzes the reversible transamination of tyrosine to p-hydrophenylpyruvate, an important step in tyrosine metabolism
  • plays an important suppressive role in the development and progression of hepatocellular carcinoma
  • catalyzes the transamination of tyrosine and other aromatic amino acids
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
  • second step of the phenylalanine catabolism
  • first step of the tyrosine catabolism
  • a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • pyridoxal phosphate
  • protein
  • TAT promotes the release of CCNT1 from the 7SK RNP through direct binding to the 7SK RNA
  • cell & other
    REGULATION
    induced by a factor of unknown nature launching the mechanism of TAT induction independently of cortisol, a classic TAT inducer
    ASSOCIATED DISORDERS
    corresponding disease(s) TATD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    in primary hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS