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FLASH GENE

Symbol

TAS1R2

contributors: mct - updated : 26-04-2017

HGNC name	taste receptor, type 1, member 2
HGNC id	14905

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p36.13      Physical location : 19.166.092 - 19.186.155
Synonym name	G protein-coupled receptor 71
	sweet taste receptor T1R2
Synonym symbol(s)	TR2, T1R2, GPR71
EC.number	1.5.1.12

DNA

TYPE	functioning gene
STRUCTURE	20.06 kb     6 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

regionally located

with TAS1R1 and TAS1R3 within a small region of chromosome 1p36

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_152232 6 - 2521 NP_689418 - 839 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose       Homo sapiens Epithelial sensory gustatory

cells

System Cell Pubmed Species Stage Rna symbol Gustatory clear receptor cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal extracellular binding domain
	seven transmembrane segments (7TM)

conjugated

GlycoP

mono polymer

heteromer , dimer

HOMOLOGY

interspecies

homolog to murine Tas1r2 (69.7pc)

intraspecies	paralog to TAS1R1
	paralog to TAS1R3

Homologene

FAMILY	G-protein coupled receptor 3 family
	taste receptor family
	sweet receptor subfamily

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	acting as a metabotropic glutamate, GABA-B-like receptor
	with TAS1R3, in addition to their role in taste perception, may also have a role in intrahepatic cholangiocytes (Toyono 2007)
	with TAS1R3, mediating sweet taste perception (Fushan 2009)
	TAS1R2/TAS1R3 are involved in glucose-dependent secretion of satiation peptides
	effects of artificial sweeteners on adipose tissue biology may be largely independent of the classical sweet taste receptors, TAS1R2 and TAS1R3
	TAS1R2 and TAS1R3 are likely to have a novel membrane trafficking system
	TAS1R2/TAS1R3 are expressed in taste bud cells in the oral cavity and involved in membrane glucose sensing in endocrine cells regulating glucose homeostasis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction , sensory transduction/taste

sweet receptor

a component	forming heterodimers with TAS1R3
	heterodimerization of TAS1R2 and TAS1R3 is required for the perception of sweet substances

INTERACTION

DNA

RNA

small molecule

protein

L-amino acids "sweet" ligands

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS