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FLASH GENE
Symbol TAS1R2 contributors: mct - updated : 26-04-2017
HGNC name taste receptor, type 1, member 2
HGNC id 14905
DNA
TYPE functioning gene
STRUCTURE 20.06 kb     6 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
regionally located with TAS1R1 and TAS1R3 within a small region of chromosome 1p36
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 2521 - 839 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose    Homo sapiens
Epithelialsensorygustatory  
cells
SystemCellPubmedSpeciesStageRna symbol
Gustatoryclear receptor cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal extracellular binding domain
  • seven transmembrane segments (7TM)
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Tas1r2 (69.7pc)
    intraspecies paralog to TAS1R1
    paralog to TAS1R3
    Homologene
    FAMILY
  • G-protein coupled receptor 3 family
  • taste receptor family
  • sweet receptor subfamily
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • acting as a metabotropic glutamate, GABA-B-like receptor
  • with TAS1R3, in addition to their role in taste perception, may also have a role in intrahepatic cholangiocytes (Toyono 2007)
  • with TAS1R3, mediating sweet taste perception (Fushan 2009)
  • TAS1R2/TAS1R3 are involved in glucose-dependent secretion of satiation peptides
  • effects of artificial sweeteners on adipose tissue biology may be largely independent of the classical sweet taste receptors, TAS1R2 and TAS1R3
  • TAS1R2 and TAS1R3 are likely to have a novel membrane trafficking system
  • TAS1R2/TAS1R3 are expressed in taste bud cells in the oral cavity and involved in membrane glucose sensing in endocrine cells regulating glucose homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction , sensory transduction/taste
    sweet receptor
    a component
  • forming heterodimers with TAS1R3
  • heterodimerization of TAS1R2 and TAS1R3 is required for the perception of sweet substances
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • L-amino acids "sweet" ligands
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS