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FLASH GENE
Symbol TAS1R2 contributors: mct - updated : 26-04-2017
HGNC name taste receptor, type 1, member 2
HGNC id 14905
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal extracellular binding domain
  • seven transmembrane segments (7TM)
    • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Tas1r2 (69.7pc)
    intraspecies paralog to TAS1R1
    paralog to TAS1R3
    Homologene
    FAMILY
  • G-protein coupled receptor 3 family
  • taste receptor family
  • sweet receptor subfamily
    • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • acting as a metabotropic glutamate, GABA-B-like receptor
  • with TAS1R3, in addition to their role in taste perception, may also have a role in intrahepatic cholangiocytes (Toyono 2007)
  • with TAS1R3, mediating sweet taste perception (Fushan 2009)
  • TAS1R2/TAS1R3 are involved in glucose-dependent secretion of satiation peptides
  • effects of artificial sweeteners on adipose tissue biology may be largely independent of the classical sweet taste receptors, TAS1R2 and TAS1R3
  • TAS1R2 and TAS1R3 are likely to have a novel membrane trafficking system
  • TAS1R2/TAS1R3 are expressed in taste bud cells in the oral cavity and involved in membrane glucose sensing in endocrine cells regulating glucose homeostasis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction , sensory transduction/taste
    sweet receptor
    a component
  • forming heterodimers with TAS1R3
  • heterodimerization of TAS1R2 and TAS1R3 is required for the perception of sweet substances
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • L-amino acids "sweet" ligands
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS