protein
| binds to DRG1 |
|
binds to the LIM domain containing protein Rhombotin-2 |
|
associates with many binding partners including E2A, GATA1, LMO2, LDB1, and ETO2, all of which are involved in modulating hematopoietic cell growth and differentiation  |
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TAL1 expression activated UBE2H expression, whereas TAL1 knock-down reduced UBE2H expression and ubiquitin transfer activity  |
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interacts with RUNX1 and ETS1, and these transcription factors are critically required for TAL1 binding to genes that modulate T-cell differentiation  |
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interacting with TRIM33 (regulation of adult hematopoiesis through TRIM33-mediated transcriptional repression of TAL1 and SPI1 target genes)  |
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interplay between PRKACA phosphorylation and TAL1-mediated epigenetic regulation that regulates hematopoietic transcription and differentiation programs during hematopoiesis and leukemogenesis  |
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GATA1 coregulators ZFPM1 and TAL1 dissociate from mitotic chromatin, suggesting that GATA1 functions as platform for their postmitotic recruitment  |
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forced TAL1 expression increases EPOR and erythropoietin hypersensitivity in erythroid progenitors  |
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TAL1 associates with GATA1, GATA2, lim-only protein LMO2, and LDB1 in a multimeric complex to regulate erythroid transcription  |
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TAL1 can recruit GATA1 and increase GATA1 binding to the EPOR promoter region to stimulate gene expression  |
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GATA1-dependent looping mechanisms may facilitate the conservation of TAL1 regulation despite cis-regulatory remodeling during vertebrate evolution  |
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GATA1 and TAL1 are bound to the regulatory regions of TFDP2 and upregulate its expression  |
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KLF1 plays a role in facilitating and/or stabilizing GATA1 and TAL1 occupancy in the erythroid genes, contributing to the generation of active chromatin structure such as histone acetylation and chromatin looping  |
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in human hematopoietic stem/progenitor cells (HSPCs) DDIT4 is a direct TAL1 target gene  |
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link between TAL1 and the MTOR pathway in human early hematopoietic cells |
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TAL1 together with hematopoietic transcription factors RUNX1 and GATA1 binds to the promoter of the isoform 3 of PRKACB  |
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
| translocation
|  
|  
|
translocation t(1;14) (p34,q11) or deletion in T cell acute lymphoblastic leukemia with worse response to treatment | tumoral
|  
|  
|  
| gain of function
|
Aberrant activation is involved in up to 60p100 of T cell acute lymphoblastic leukemia (T-ALL) cases, indicating that misregulation of TAL1's activity may lead to the development of T cell leukemia  | tumoral
|  
|  
| --other
|  
|
with LYL1, aberrantly over-expressed in leukemia as a result of chromosomal translocations | tumoral
|  
|  
| --low
|  
|
by aberrant methylation of TAL1 in pediatric B-cell acute lymphoblastic leukemia (pMID: 25830127) | tumoral
|  
|  
|  
| gain of function
|
aberrant TAL1 activation is mediated by an interchromosomal interaction in human T-cell acute lymphoblastic leukemia  | |