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GENATLAS PHENOTYPE
last update : 30-03-2018
Symbol TAL1
Location 1p33
Name T-cell acute lymphocytic leukemia 1
Corresponding gene TAL1
Main clinical features
  • interstitial deletion 5' to TAL1 (stem-cell leukemia) or with translocations t(1;14)(p32;q11), t(1;7)(p32;p35), t(1;3)(p34;p21), t(1;5)(p32;q31), see SCL, SIL, TCTA
    • Genetic determination not applicable
    Function/system disorder hematology
    Type malignancy
    Gene product
    Name chimeric fusion protein 5' - SIL - SCL - 3'
    Mechanism(s)
    Gene mutationChromosome rearrangementEffectComments
      translocation   somatic, tumoral
      deletion   somatic, tumoral
    Remark(s)