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FLASH GENE
Symbol TAF5L contributors: - updated : 15-11-2005
HGNC name TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
HGNC id 17304
Location 1q42.13      Physical location : 229.728.867 - 229.761.794
Synonym name p300/CBP-associated factor (PCAF)-associated factor, 65 kD
Synonym symbol(s) PAF65B
DNA
TYPE functioning gene
STRUCTURE 32.00 kb     5 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
TRIM11 1q42.13 tripartite motif-containing 11 TRIM17 1q42 tripartite motif-containing 17 HIST3H3 1q42 histone 3, H3 LOC391175 1 similar to 60S ribosomal protein L23a HIST3H2A 1q42.13 histone 3, H2a HIST3H2BB 1q42.13 histone 3, H2bb HIST3H2BA 1 histone 3, H2ba LOC149603 1q42.13 hypothetical protein LOC149603 FLJ31401 1q42.13 hypothetical protein FLJ31401 LOC388750 1 similar to Ferritin heavy chain (Ferritin H subunit) ARHU 1q42.11-q42.3 ras homolog gene family, member U LOC388751 1 LOC388751 RAB4A 1q42-q43 RAB4A, member RAS oncogene family SPHAR 1q42.11-q42.3 S-phase response (cyclin-related) LOC126731 1q42.13 LOC126731 ACTA1 1q42.13-q42.2 actin, alpha 1, skeletal muscle NUP133 1q42.13 nucleoporin 133kDa ABCB10 1q42 ATP-binding cassette, sub-family B (MDR/TAP), member 10 TAF5L 1q42.13 TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa KIAA0133 1q42.13 TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa LOC391177 1 similar to HMG-1 LOC388752 1 LOC388752 GALNT2 1q41-q42 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2) PGBD5 1q42.13 piggyBac transposable element derived 5
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 3122 - 589 - -
variant 1 represents the shorter variant but encodes the longer isoform a
- splicing 4139 - 325 - -
differs in the 5' UTR and the 5' coding region, compared to variant 1, the resulting isoform (b) contains a distinct N-terminus, compared to isoform a
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivemouthtongue  highly
Reproductivefemale systembreastmammary gland  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
six WD repeats
HOMOLOGY
Homologene
FAMILY WD-repeat TAF5 family
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • may be playing an efficient role in acetylating histones in a nucleosomal context
  • may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation
  • CELLULAR PROCESS cell life, antiapoptosis
    nucleotide, transcription, initiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the PCAF histone acetylase complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by PCNA
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene for diabete type 1 in russian patients
    Marker
    Therapy target
    ANIMAL & CELL MODELS