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FLASH GENE

Symbol

TAF5L

contributors: - updated : 15-11-2005

HGNC name	TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
HGNC id	17304

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	32.00 kb     5 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - splicing 3122 - 589 - - variant 1 represents the shorter variant but encodes the longer isoform a variant 2 - splicing 4139 - 325 - - differs in the 5' UTR and the 5' coding region, compared to variant 1, the resulting isoform (b) contains a distinct N-terminus, compared to isoform a

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive mouth tongue     highly Reproductive female system breast mammary gland

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

six WD repeats

HOMOLOGY

Homologene

FAMILY

WD-repeat TAF5 family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	may be playing an efficient role in acetylating histones in a nucleosomal context
	may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation

CELLULAR PROCESS	cell life, antiapoptosis
	nucleotide, transcription, initiation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of the PCAF histone acetylase complex

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

Other

regulated by PCNA

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene	for diabete type 1 in russian patients
Marker
Therapy target

ANIMAL & CELL MODELS