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FLASH GENE
Symbol TAF15 contributors: mct/npt/shn - updated : 04-11-2013
HGNC name TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
HGNC id 11547
Location 17q12      Physical location : 34.136.487 - 34.174.237
Synonym name
  • RNA binding protein 56
  • TATA-binding protein-associated factor II 68
  • RBP56/CSMF fusion
  • TATA box-binding protein-associated factor 2N (RNA-binding
    • protein 56)
  • TATA-binding protein-associated factor 2N
  • TATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD (RNA-binding protein 56)
  • TBP-associated factor 15
    • Synonym symbol(s) TAF2N, RBP56, TAF268, TAF(II)68, Npl3, TAFII68
    DNA
    TYPE functioning gene
    STRUCTURE 37.75 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D17S1846 - D17S1833 - TAF15 - D17S927 - D17S1867 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 splicing 2153 - 592 - Alves (2009)
    16 splicing 2166 - 589 - Alves (2009)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly Homo sapiensAdult
    Digestiveliver   highly Homo sapiensAdult
     liver   highly Homo sapiensFetal
    Endocrinepancreas   highly Homo sapiensAdult
    Nervousbrain   highly Homo sapiensAdult
     brain   highly Homo sapiensFetal
    Reproductivefemale systemplacenta  highly Homo sapiensAdult
    Respiratorylung   highly Homo sapiensAdult
     lung   highly Homo sapiensFetal
    Urinarykidney   highly Homo sapiensFetal
     kidney   highly Homo sapiensAdult
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly Homo sapiensAdult
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a consensus RNA-binding domain (RNP-CS)
  • a N terminal SER, TYR, GLU, GLY rich domain, and transactivation domain, that serves as an essential transforming domain in the fusion oncoprotein created by chromosomal translocation in certain human chondrosarcomas
  • zinc finger domain
  • an RNA recognition motif (RRM)
  • C2-C2 finger motif in the central region
  • a C terminal RGG region, containing 19 repeats of degenerate DR(S) GG(G)-YGG sequence, and many Arg-Gly-Gly (RGG) repeats, responsible for the shuttling between the nucleus and the cytoplasm and the methylation of RGG repeats affects the subcellular localization of TAF15 (Jobert 2009)
    • HOMOLOGY
    interspecies ortholog to taf15, Danio rerio
    ortholog to TAF15, Pan troglodytes
    ortholog to Taf15, Mus musculus
    ortholog to Taf15, Rattus norvegicus
    intraspecies homolog to EWS,FUS,highly
    Homologene
    FAMILY
  • FET (FUS, EWS, TAF15) family of RNA- and DNA-binding proteins
    • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text the RGG repeat-containing C-terminus of TAF15 is responsible for the shuttling between the nucleus and the cytoplasm and the methylation of RGG repeats affects the subcellular localization of TAF15 (Jobert 2009)
    basic FUNCTION
  • playing a specific role during transcription initiation at distinct promoters
  • is required to regulate gene expression of cell cycle regulatory genes post-transcriptionally through a pathway involving miRNAs
  • key regulator of maintaining a highly proliferative rate of cellular homeostasis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • family of multifunctional proteins known as TET that comprises TLS/FUS (translocated in liposarcoma), EWSR1 (Ewing sarcoma) and TAF15 (Alves 2009)
    • INTERACTION
    DNA single stranded (ss) DNA
    RNA RNA
    small molecule
    protein
  • TFIID
  • RNA polymerase II holoenzyme
  • SAFB1RD
  • PRMT1 (Jobert (2009)
    • cell & other
    REGULATION
    Other arginine methylation of TAF15 by PRMT1 is a crucial event determining its proper localization and gene regulatory function (Jobert 2009)
    specifically cleaved by caspases-3 and -7 (Alves 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with TEC in extraskeletal myxoid chondrosarcoma (Kim 2008)
    tumoral   translocation    
    involved in acute leukemia through fusion with ZNF384 (Martini 2002)
    tumoral     --over  
    in liposarcoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene Amyotrophic lateral sclerosis
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • G391E, R408C, and G473E TAF15 variants caused formation of cytoplasmic foci when expressed in primary cultures of spinal cord neurons
  • TAF15 Up-Regulation Causes Neurodegeneration in Drosophila
  • Immunohistochemistry of postmortem spinal cord tissue revealed mislocalization of TAF15 in motor neurons of patients with amyotrophic lateral sclerosis