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FLASH GENE
Symbol TAF15 contributors: mct/npt/shn - updated : 04-11-2013
HGNC name TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
HGNC id 11547
DNA
TYPE functioning gene
STRUCTURE 37.75 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D17S1846 - D17S1833 - TAF15 - D17S927 - D17S1867 - qter
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 splicing 2153 - 592 - Alves (2009)
16 splicing 2166 - 589 - Alves (2009)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly Homo sapiensAdult
Digestiveliver   highly Homo sapiensAdult
 liver   highly Homo sapiensFetal
Endocrinepancreas   highly Homo sapiensAdult
Nervousbrain   highly Homo sapiensAdult
 brain   highly Homo sapiensFetal
Reproductivefemale systemplacenta  highly Homo sapiensAdult
Respiratorylung   highly Homo sapiensAdult
 lung   highly Homo sapiensFetal
Urinarykidney   highly Homo sapiensFetal
 kidney   highly Homo sapiensAdult
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly Homo sapiensAdult
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a consensus RNA-binding domain (RNP-CS)
  • a N terminal SER, TYR, GLU, GLY rich domain, and transactivation domain, that serves as an essential transforming domain in the fusion oncoprotein created by chromosomal translocation in certain human chondrosarcomas
  • zinc finger domain
  • an RNA recognition motif (RRM)
  • C2-C2 finger motif in the central region
  • a C terminal RGG region, containing 19 repeats of degenerate DR(S) GG(G)-YGG sequence, and many Arg-Gly-Gly (RGG) repeats, responsible for the shuttling between the nucleus and the cytoplasm and the methylation of RGG repeats affects the subcellular localization of TAF15 (Jobert 2009)
  • HOMOLOGY
    interspecies ortholog to taf15, Danio rerio
    ortholog to TAF15, Pan troglodytes
    ortholog to Taf15, Mus musculus
    ortholog to Taf15, Rattus norvegicus
    intraspecies homolog to EWS,FUS,highly
    Homologene
    FAMILY
  • FET (FUS, EWS, TAF15) family of RNA- and DNA-binding proteins
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text the RGG repeat-containing C-terminus of TAF15 is responsible for the shuttling between the nucleus and the cytoplasm and the methylation of RGG repeats affects the subcellular localization of TAF15 (Jobert 2009)
    basic FUNCTION
  • playing a specific role during transcription initiation at distinct promoters
  • is required to regulate gene expression of cell cycle regulatory genes post-transcriptionally through a pathway involving miRNAs
  • key regulator of maintaining a highly proliferative rate of cellular homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • family of multifunctional proteins known as TET that comprises TLS/FUS (translocated in liposarcoma), EWSR1 (Ewing sarcoma) and TAF15 (Alves 2009)
  • INTERACTION
    DNA single stranded (ss) DNA
    RNA RNA
    small molecule
    protein
  • TFIID
  • RNA polymerase II holoenzyme
  • SAFB1RD
  • PRMT1 (Jobert (2009)
  • cell & other
    REGULATION
    Other arginine methylation of TAF15 by PRMT1 is a crucial event determining its proper localization and gene regulatory function (Jobert 2009)
    specifically cleaved by caspases-3 and -7 (Alves 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with TEC in extraskeletal myxoid chondrosarcoma (Kim 2008)
    tumoral   translocation    
    involved in acute leukemia through fusion with ZNF384 (Martini 2002)
    tumoral     --over  
    in liposarcoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene Amyotrophic lateral sclerosis
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • G391E, R408C, and G473E TAF15 variants caused formation of cytoplasmic foci when expressed in primary cultures of spinal cord neurons
  • TAF15 Up-Regulation Causes Neurodegeneration in Drosophila
  • Immunohistochemistry of postmortem spinal cord tissue revealed mislocalization of TAF15 in motor neurons of patients with amyotrophic lateral sclerosis