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FLASH GENE
Symbol STRADA contributors: shn/npt/pgu - updated : 02-11-2009
HGNC name STE20-related kinase adaptor alpha
HGNC id 30172
Corresponding disease
PMSE polyhydramnios, megalencephaly and symptomatic epilepsy
Location 17q23.3      Physical location : 61.780.193 - 61.819.330
Synonym name
  • STE20-related adaptor protein
  • STRAD alpha
  • protein kinase LYK5
  • serologically defined breast cancer antigen NY-BR-96
  • STE20-like pseudokinase
  • Synonym symbol(s) STRAD, FLJ90524, LYK5, NY-BR-96, Stlk
    EC.number 2.7.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 39.02 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map cen - D17S948 - D17S944 - STRADA - D17S1297 - D17S1809 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2144 - 299 - 2008 18687677
    10 - 2189 - 314 - 2008 18687677
    13 - 2223 48.4 431 - 2008 18687677
    11 - 2112 - 394 - 2008 18687677
    9 - 2658 - 348 - 2008 18687677
    12 - 2194 - 373 - 2008 18687677
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a STE20 -like kinase domain, but it lacks several residues that are indispensable for intrinsic catalytic activity
  • a PAPA box (proline-alanine repeats)
  • HOMOLOGY
    interspecies ortholog to Strada, Mus musculus
    ortholog to Strada, rattus norvegicus
    ortholog to strada, danio rerio
    ortholog to STRADA, Pan troglodytes
    Homologene
    FAMILY
  • protein kinase superfamily
  • ser/thr protein kinase family
  • ste20 subfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • may act as a mediator of stress-activated signals
  • pseudokinase necessary for proper localization and function of serine/threonine kinase 11 (STK11)
  • induces relocalization of STK11 from the nucleus to the cytoplasm and stimulates its catalytic activity
  • facilitates nuclear export of STK11 by serving as an adaptor between STK11 and exportins XPO1 and XPO7
  • having ability to activate STK11, dependent on a closed "active" conformation, aided by ATP and CAB39 binding
  • activates the STK11 tumour suppressor by forming a heterotrimeric complex with STK111 and the scaffolding protein CAB39
  • involved with CAB39 in STK11 activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with STK11, complex in which LYK5 activates LKB1, resulting in phosphorylation of both partners
  • forms a heterotrimeric complex with the scaffolding protein CAB39 and the tumor suppressor serine threonine protein kinase STK11, involved in the regulation of numerous signaling pathways including metabolism, proliferation and cellular polarity of intestinal epithelial cells )
  • core heterotrimeric STK11-STRADA-CAB39 complex, implicated in unusual allosteric mechanism of STK11 activation
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • serine/threonine kinase 11 (STK1)
  • STRADA deacetylation regulated by SIRT1
  • STK11
  • STRADA complex could regulate neuronal polarization involving phosphorylation and activation of BRSK2 and BRSK1
  • forms a heterotrimeric complex with serine/threonine kinase 11 (STK11) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PMSE
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS