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FLASH GENE

Symbol

STRADA

contributors: shn/npt/pgu - updated : 02-11-2009

HGNC name	STE20-related kinase adaptor alpha
HGNC id	30172

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	PMSE polyhydramnios, megalencephaly and symptomatic epilepsy
Location	17q23.3      Physical location : 61.780.193 - 61.819.330
Synonym name	STE20-related adaptor protein
	STRAD alpha
	protein kinase LYK5
	serologically defined breast cancer antigen NY-BR-96
	STE20-like pseudokinase
Synonym symbol(s)	STRAD, FLJ90524, LYK5, NY-BR-96, Stlk
EC.number	2.7.1.-

DNA

TYPE	functioning gene
STRUCTURE	39.02 kb     12 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - D17S948 - D17S944 - STRADA - D17S1297 - D17S1809 - qter

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001165970 (transcript variant 6) 11 - 2144 NP_001159442 - 299 - 2008 18687677 NM_001165969 (transcript variant 5) 10 - 2189 NP_001159441 - 314 - 2008 18687677 NM_001003787 (transcript variant 1) 13 - 2223 NP_001003787 48.4 431 - 2008 18687677 NM_001003786 (transcript variant 2) 11 - 2112 NP_001003786 - 394 - 2008 18687677 NM_153335 (transcript variant 3) 9 - 2658 NP_699166 - 348 - 2008 18687677 NM_001003788 (transcript variant 4) 12 - 2194 NP_001003788 - 373 - 2008 18687677

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a STE20 -like kinase domain, but it lacks several residues that are indispensable for intrinsic catalytic activity
	a PAPA box (proline-alanine repeats)

HOMOLOGY

interspecies	ortholog to Strada, Mus musculus
	ortholog to Strada, rattus norvegicus
	ortholog to strada, danio rerio
	ortholog to STRADA, Pan troglodytes

Homologene

FAMILY	protein kinase superfamily
	ser/thr protein kinase family
	ste20 subfamily

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	may act as a mediator of stress-activated signals
	pseudokinase necessary for proper localization and function of serine/threonine kinase 11 (STK11)
	induces relocalization of STK11 from the nucleus to the cytoplasm and stimulates its catalytic activity
	facilitates nuclear export of STK11 by serving as an adaptor between STK11 and exportins XPO1 and XPO7
	having ability to activate STK11, dependent on a closed "active" conformation, aided by ATP and CAB39 binding
	activates the STK11 tumour suppressor by forming a heterotrimeric complex with STK111 and the scaffolding protein CAB39
	involved with CAB39 in STK11 activity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	complexing with STK11, complex in which LYK5 activates LKB1, resulting in phosphorylation of both partners
	forms a heterotrimeric complex with the scaffolding protein CAB39 and the tumor suppressor serine threonine protein kinase STK11, involved in the regulation of numerous signaling pathways including metabolism, proliferation and cellular polarity of intestinal epithelial cells )
	core heterotrimeric STK11-STRADA-CAB39 complex, implicated in unusual allosteric mechanism of STK11 activation

INTERACTION

DNA

RNA

small molecule

protein	serine/threonine kinase 11 (STK1)
	STRADA deacetylation regulated by SIRT1
	STK11
	STRADA complex could regulate neuronal polarization involving phosphorylation and activation of BRSK2 and BRSK1
	forms a heterotrimeric complex with serine/threonine kinase 11 (STK11) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

PMSE

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS