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FLASH GENE
Symbol STRADA contributors: shn/npt/pgu - updated : 14-06-2016
HGNC name STE20-related kinase adaptor alpha
HGNC id 30172
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 2144 - 299 - 2008 18687677
10 - 2189 - 314 - 2008 18687677
13 - 2223 48.4 431 - 2008 18687677
11 - 2112 - 394 - 2008 18687677
9 - 2658 - 348 - 2008 18687677
12 - 2194 - 373 - 2008 18687677
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a STE20 -like kinase domain, but it lacks several residues that are indispensable for intrinsic catalytic activity
  • a PAPA box (proline-alanine repeats)
  • HOMOLOGY
    interspecies ortholog to Strada, Mus musculus
    ortholog to Strada, rattus norvegicus
    ortholog to strada, danio rerio
    ortholog to STRADA, Pan troglodytes
    Homologene
    FAMILY
  • protein kinase superfamily
  • ser/thr protein kinase family
  • ste20 subfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • may act as a mediator of stress-activated signals
  • pseudokinase necessary for proper localization and function of serine/threonine kinase 11 (STK11)
  • induces relocalization of STK11 from the nucleus to the cytoplasm and stimulates its catalytic activity
  • facilitates nuclear export of STK11 by serving as an adaptor between STK11 and exportins XPO1 and XPO7
  • having ability to activate STK11, dependent on a closed "active" conformation, aided by ATP and CAB39 binding
  • activates the STK11 tumour suppressor by forming a heterotrimeric complex with STK111 and the scaffolding protein CAB39
  • involved with CAB39 in STK11 activity
  • can function independently of STK11 to regulate cell polarity and invasion via PAK1 when STK11 function is compromised
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • STRADA-STK11 pathway plays critical roles in epithelial cell polarity, neuronal polarity, and cancer metastasis
  • a component
  • complexing with STK11, complex in which LYK5 activates LKB1, resulting in phosphorylation of both partners
  • forms a heterotrimeric complex with the scaffolding protein CAB39 and the tumor suppressor serine threonine protein kinase STK11, involved in the regulation of numerous signaling pathways including metabolism, proliferation and cellular polarity of intestinal epithelial cells )
  • core heterotrimeric STK11-STRADA-CAB39 complex, implicated in unusual allosteric mechanism of STK11 activation
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • serine/threonine kinase 11 (STK1)
  • STRADA deacetylation regulated by SIRT1
  • STK11/STRADA complex could regulate neuronal polarization involving phosphorylation and activation of BRSK2 and BRSK1
  • forms a heterotrimeric complex with serine/threonine kinase 11 (STK11) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25)
  • normally binds and exports the protein kinase STK11 out of the nucleus, leading to suppression of the MTOR pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PMSE
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS