basic FUNCTION
| may act as a mediator of stress-activated signals |
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pseudokinase necessary for proper localization and function of serine/threonine kinase 11 (STK11) |
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induces relocalization of STK11 from the nucleus to the cytoplasm and stimulates its catalytic activity |
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facilitates nuclear export of STK11 by serving as an adaptor between STK11 and exportins XPO1 and XPO7 |
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having ability to activate STK11, dependent on a closed "active" conformation, aided by ATP and CAB39 binding |
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activates the STK11 tumour suppressor by forming a heterotrimeric complex with STK111 and the scaffolding protein CAB39 |
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involved with CAB39 in STK11 activity |
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can function independently of STK11 to regulate cell polarity and invasion via PAK1 when STK11 function is compromised |