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FLASH GENE
Symbol STK25 contributors: mct - updated : 27-03-2018
HGNC name serine/threonine kinase 25 (STE20 homolog, yeast)
HGNC id 11404
Corresponding disease
DEL2Q37 chromosome 2q subtelomeric deletion syndrome
Location 2q37.3      Physical location : 242.434.432 - 242.448.034
Synonym name
  • sterile 20 (oxidant stress response kinase 1
  • yeast Sps1/Ste20-related kinase 1)
  • Synonym symbol(s) SOK1, YSK1
    EC.number 2.7.1.37/ 2.7.11.1
    DNA
    TYPE like-sequence
    STRUCTURE 15.02 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    MAPPING cloned Y linked   status provisional
    Map cen - D2S2158 - COL4A3 - D2S396 - D2S172 - D2S206 - D2S331 - D2S2202 - D2S345 - D2S2338 - STK25 - D2S2285 - D2S125 - qter
    Authors Gene Map (98)
    Physical map
    LOC150678 2q37.3 helicase/primase complex protein LOC150677 LOC391497 2 similar to ENSANGP00000007346 GPC1 2q37.3 glypican 1 ANKMY1 2q37.3 ankyrin repeat and MYND domain containing 1 LOC285193 2q37.3 similar to RIKEN cDNA 0710001B24 RNPEPL1 2q37.3 arginyl aminopeptidase (aminopeptidase B)-like 1 CAPN10 2q37.3 calpain 10 GPR35 2q37.3 G protein-coupled receptor 35 LOC285192 2q37.3 similar to aquaporin 11 AQP12 2q37.3 aquaporin 12 ATSV 2q37.3 axonal transport of synaptic vesicles AGXT 2q37.3 alanine-glyoxylate aminotransferase (oxalosis I; hyperoxaluria I; glycolicaciduria; serine-pyruvate aminotransferase) FLJ22671 2q37.3 hypothetical protein FLJ22671 LOC285188 2q37.3 similar to KIAA0445 protein FLJ00133 2q37.3 FLJ00133 protein MGC61716 2q37.3 hypothetical protein MGC61716 PASK 2q37.3 PAS domain containing serine/threonine kinase PPP1R7 2q37.3 protein phosphatase 1, regulatory subunit 7 LOC344525 2q37.3 similar to transmembrane protein 16C; chromosome 11 open reading frame 25 HDLBP 2q37.3 high density lipoprotein binding protein (vigilin) NEDD5 2q37. neural precursor cell expressed, developmentally down-regulated 5 FARP2 2q37.3 FERM, RhoGEF and pleckstrin domain protein 2 STK25 2q37.3 serine/threonine kinase 25 (STE20 homolog, yeast) BOK 2q37.3 BCL2-related ovarian killer LOC391498 2 similar to Involucrin THAP4 2q37.3 THAP domain containing 4 APG4B 2q37.3 cysteine endopeptidase AUT-like isoform 1 DTYMK 2pter-p25.2 deoxythymidylate kinase (thymidylate kinase) ING5 2q37.3 inhibitor of growth family, member 5 GP3ST 2q37.3 inhibitor of growth family, member 5 NEU4 2q37.3 sialidase 4 LOC391499 ATTS1136 similar to EST gb FLJ38379 2q37.3 hypothetical protein FLJ38379 LOC159176 2q37.3 similar to F-box only protein 25
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2527 - 426 - 2016 26553096
    11 - 2556 - 332 - 2016 26553096
    11 - 2397 - 332 - 2016 26553096
    11 - 2296 - 349 - 2016 26553096
    11 - 2459 - 332 - 2016 26553096
    11 - 2358 - 349 - 2016 26553096
    12 - 2539 - 352 - 2016 26553096
    12 - 2589 - 426 - 2016 26553096
    11 - 2561 - 426 - 2016 26553096
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinelarge intestine  highly
     stomach   highly
    Nervousbrain   highly
    Reproductivemale systemtestis  highly
    Respiratorylung   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    kinase domain in N terminus
    HOMOLOGY
    interspecies homolog to C.elegans f14h12.4
    Homologene
    FAMILY
  • serine/threonine kinase family, GCK III subfamily
  • Ste20 superfamily of kinases
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • functioning in a signaling pathway required for cell migration and polarization
  • play distinctly different roles in stressed versus non-stressed cells, regulating cell death in the former
  • can induce cell death entering the nucleus, but this is not necessarily the only way it can kill a cell
  • RELN and STK25 have opposing roles in neuronal polarization and dendritic Golgi deployment
  • STK25 regulates lipid partitioning in human liver cells by controlling triacylglycerol (TAG) synthesis as well as lipolytic activity
  • is a critical regulator of ectopic lipid deposition, systemic glucose, and insulin homeostasis
  • multiple roles of STK25 in nonalcoholic steatohepatitis (NASH) pathogenesis
  • is a critical regulator of liver steatosis, hepatic lipid metabolism and whole body glucose and insulin homeostasis
  • STK25 emerges as a new regulator of the complex interplay between lipid storage, mitochondrial energetics and insulin action in skeletal muscle
  • is a critical regulator of ectopic fat storage, meta-inflammation, and fibrosis in liver and skeletal muscle
  • is a critical regulator of energy homeostasis and Nonalcoholic fatty liver disease (NAFLD) progression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • PDCD10 can heterodimerize with GCKIII kinases (STK24, MST4, and STK25) to regulate cardiovascular development
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • activated by the Golgi matrix protein GOLGA2 and plays a role in cell migration through its substrate YWHAZ
  • STK25 regulates neuronal polarization and Golgi morphology in an antagonistic manner to DAB1
  • PDCD10 interacts with STK25, an oxidant stress response kinase related to sterile-20 (Ste20) that is activated by oxidative stress and induces apoptotic cell death
  • CCM2 can be phosphorylated by STK25, and the kinase activity of STK25 is required for death signaling
  • STK26 and STK25 belong to the Ste20-like kinases and interact with PDCD10 which is closely linked to cancer diseases
  • cell & other
    REGULATION
    activated by oxidant stress and by autophosphorylation
    not activated by growth factors,alkylating agents,cytokines or environmental stress
    chemical anoxia in a caspase-independent manner, something that has not been described for any other of the GCKIII family members
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL2Q37
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in conditions of excess dietary fuels associates with a shift in the metabolic balance in peripheral tissues from lipid oxidation to storage, leading to a systemic insulin resistance
    tumoral     --over  
    in prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene pseudopseudohypoparathyroidism (PPHP)
    for brachymetaphalangism and/or obesity in the del2q37 syndrome
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabete  
    reducing STK25 function may provide a new strategy for the treatment of patients with type 2 diabetes
    digestiveliver 
    reducing STK25 function may provide a new strategy for the treatment of patients with Nonalcoholic fatty liver disease (NAFLD)
    metabolism  
    potential drug target for metabolic disease
    ANIMAL & CELL MODELS
  • Stk25-/- mice are protected against methionine and choline-deficient (MCD) diet-induced NASH, as evidenced by repressed liver steatosis, oxidative damage, inflammation, and fibrosis, whereas Stk25 transgenic mice developed a more severe nonalcoholic steatohepatitis (NASH) phenotype, compared with corresponding wild-type littermates
  • transgenic mice overexpressing STK25, when challenged with a high-fat diet, develop reduced glucose tolerance and insulin sensitivity compared to wild-type siblings