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FLASH GENE
Symbol STEAP3 contributors: mct - updated : 02-07-2014
HGNC name STEAP family member 3
HGNC id 24592
Corresponding disease
AHMIO2 anemia, hypochromic microcytic, with iron overload 2
Location 2q14.2      Physical location : 119.981.383 - 120.023.225
Genatlas name pHyde
Synonym name
  • dudulin 2
  • dudlin 2
  • six transmembrane prostate protein 3
  • tumor suppressor activated pathway-6
  • p53-inducible 5-6 transmembrane protein
  • six-transmembrane epithelial antigen of prostate 3
  • tumor suppressor pHyde
  • tumor suppressor activated pathway-6
  • Synonym symbol(s) STMP3, TSAP6, dudlin-2, pHyde, AHMIO2
    EC.number 1.16.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 41.85 kb     6 Exon(s)
    regulatory sequence Promoter
    Binding site   HRE
    text structure a functional p53-responsive element
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 splicing 3870 54.5 488 - 2004 15319436
  • lacking an alternate exon compared to variant 1
  • encoding the same isoform than variant 2
  • 6 splicing 3938 54.5 488 - 2004 15319436
  • differing in the 5' UTR and coding region compared to variant 1
  • encoding the same isoform than variant 3
  • 6 splicing 4285 55.5 498 - 2004 15319436
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   moderately
     liver   moderately
    Endocrineneuroendocrinepituitary  highly
     parathyroid   predominantly
     thyroid   moderately
    Nervousnerve   highly
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Connectivebone  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • five to six transmembrane domains
  • a long N-terminal tail predicted to have NADP+/NADPH ferric oxidoreductase activity
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Steap3 (85.9 pc)
    homolog to murine Steap3 (86.4 pc)
    Homologene
    FAMILY
  • STEAP family
  • CATEGORY enzyme , regulatory , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • multipass membrane protein
  • localized to vesicular-like structures at the plasma membrane and around the nucleus
  • glycosylated protein present in the trans-Golgi network, endosomal-vesicular compartment and cytoplasmic membrane
  • basic FUNCTION
  • playing a role in the export of TPT1 and in the regulation of vesicular trafficking and secretion
  • may act downstream to TP53 to interface apoptosis and cell-cycle progression
  • acting as an endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells
  • participating in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+) using NAD(+) as acceptor
  • can also reduce of Cu(2+) to Cu(1+) using NAD(+) as acceptor, suggesting that it participates in copper homeostasis
  • exosome formation is a tightly controlled biological process dependent of STEAP3
  • indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP
  • maintains iron storage in human malignant cells and tumor proliferation under the hypoferric condition
  • ferrireductase that is involved in the acquisition of iron by developing erythroblasts
  • STEAP1, STEAP2, STEAP3, STEAP4 share an innate activity as metalloreductases, indicating their importance in metal metabolism
  • CELLULAR PROCESS cell cycle, progression
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS electron transport
    text
  • iron transport
  • electron carrier
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • FAD
  • NAD
  • Cu2+
  • Fe3+/Fe2+
  • protein
  • interacting with TPT1
  • interacting with BNIP3L and PKMYT1 to regulates apoptosis and the cell cycle
  • potential substrate of RHBDD1 inducing the proteolysis of STEAP3 in a dose- and activity-dependent manner
  • STEAP3, a metalloreductase expressed in erythroblasts, associates with TFRC and partially rescues transferrin uptake
  • cell & other
    REGULATION
    induced by TP53
    Other regulated by TP53 (TP53 regulates transcription of the genes STEAP3 and CHMP4C, which enhance exosome production, and CAV1 and CHMP4C, which produce a more rapid endosomal clearance of the epidermal growth factor receptor from the plasma membrane)
    ASSOCIATED DISORDERS
    corresponding disease(s) AHMIO2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    down-regulated in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Steap3/tsap6 null-mice display severe microcytic anemia