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FLASH GENE
Symbol STEAP3 contributors: mct - updated : 02-07-2014
HGNC name STEAP family member 3
HGNC id 24592
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five to six transmembrane domains
  • a long N-terminal tail predicted to have NADP+/NADPH ferric oxidoreductase activity
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Steap3 (85.9 pc)
    homolog to murine Steap3 (86.4 pc)
    Homologene
    FAMILY
  • STEAP family
  • CATEGORY enzyme , regulatory , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • multipass membrane protein
  • localized to vesicular-like structures at the plasma membrane and around the nucleus
  • glycosylated protein present in the trans-Golgi network, endosomal-vesicular compartment and cytoplasmic membrane
  • basic FUNCTION
  • playing a role in the export of TPT1 and in the regulation of vesicular trafficking and secretion
  • may act downstream to TP53 to interface apoptosis and cell-cycle progression
  • acting as an endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells
  • participating in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+) using NAD(+) as acceptor
  • can also reduce of Cu(2+) to Cu(1+) using NAD(+) as acceptor, suggesting that it participates in copper homeostasis
  • exosome formation is a tightly controlled biological process dependent of STEAP3
  • indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP
  • maintains iron storage in human malignant cells and tumor proliferation under the hypoferric condition
  • ferrireductase that is involved in the acquisition of iron by developing erythroblasts
  • STEAP1, STEAP2, STEAP3, STEAP4 share an innate activity as metalloreductases, indicating their importance in metal metabolism
  • CELLULAR PROCESS cell cycle, progression
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS electron transport
    text
  • iron transport
  • electron carrier
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • FAD
  • NAD
  • Cu2+
  • Fe3+/Fe2+
  • protein
  • interacting with TPT1
  • interacting with BNIP3L and PKMYT1 to regulates apoptosis and the cell cycle
  • potential substrate of RHBDD1 inducing the proteolysis of STEAP3 in a dose- and activity-dependent manner
  • STEAP3, a metalloreductase expressed in erythroblasts, associates with TFRC and partially rescues transferrin uptake
  • cell & other
    REGULATION
    induced by TP53
    Other regulated by TP53 (TP53 regulates transcription of the genes STEAP3 and CHMP4C, which enhance exosome production, and CAV1 and CHMP4C, which produce a more rapid endosomal clearance of the epidermal growth factor receptor from the plasma membrane)
    ASSOCIATED DISORDERS
    corresponding disease(s) AHMIO2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    down-regulated in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Steap3/tsap6 null-mice display severe microcytic anemia