SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,cytosolic,vesicle
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| text
| multipass membrane protein |
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localized to vesicular-like structures at the plasma membrane and around the nucleus |
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glycosylated protein present in the trans-Golgi network, endosomal-vesicular compartment and cytoplasmic membrane  |
| basic FUNCTION
| playing a role in the export of TPT1 and in the regulation of vesicular trafficking and secretion |
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may act downstream to TP53 to interface apoptosis and cell-cycle progression |
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acting as an endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells |
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participating in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+) using NAD(+) as acceptor |
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can also reduce of Cu(2+) to Cu(1+) using NAD(+) as acceptor, suggesting that it participates in copper homeostasis |
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exosome formation is a tightly controlled biological process dependent of STEAP3 |
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indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP |
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maintains iron storage in human malignant cells and tumor proliferation under the hypoferric condition |
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ferrireductase that is involved in the acquisition of iron by developing erythroblasts |
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STEAP1, STEAP2, STEAP3, STEAP4 share an innate activity as metalloreductases, indicating their importance in metal metabolism |
