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FLASH GENE
Symbol STAP1 contributors: mct/npt - updated : 22-04-2009
HGNC name signal transducing adaptor family member 1
HGNC id 24133
Location 4q13.1      Physical location : 68.424.445 - 68.472.617
Synonym name
  • docking protein BRDG1
  • stem cell adaptor protein 1
  • BCR downstream signaling 1
  • signal-transducing adaptor protein-1
    • Synonym symbol(s) BRDG1, STAP-1
    DNA
    TYPE functioning gene
    STRUCTURE 48.17 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1524 34 295 - Masuhara (2000)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    cell lineage
    cell lines B cell lines Ramos highly
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a proline rich region
  • a pleckstrin homology domain
  • SH2 domain
  • multiple tyrosine residues that are potential target sites for Src homology two domains
    • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to murine Brdg1-pending
    intraspecies homolog to ortholog of BRDG1 (BCR downstream signaling 1) mediating Tec-kinase signaling after cross-linking of the B-cell receptor
    Homologene
    FAMILY
  • protein-tyrosine kinases family
    • CATEGORY adaptor , signaling , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • functioning as a docking protein acting downstream of TEC tyrosine kinase in B cell antigen receptor signaling
  • participating in a positive feedback loop by increasing the activity of TEC
  • playing a role in pro-inflammatory microglia activation potentially contributing to neuronal apoptosis and degeneration (Stoecker 2009)
  • may control the recruitment of signaling kinases to receptor tyrosine kinases in different cell types (Stoecker 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense , cellular trafficking transport
    text
  • humoral defense mechanism
  • intracellular protein traffic
    • PATHWAY
    metabolism
    signaling signal transduction
    BCR signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • kinase domain of TEC
    • cell & other
    REGULATION
    Other phosphorylated by TEC on tyrosine residues
    phosphorylated in response to BCR stimulation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target potential candidate for therapeutic modulation of microglia activity and molecular target for limiting microglia activation in neurodegenerative disorders(Stoecker 2009)
    ANIMAL & CELL MODELS
    STAP-1-deficient mice will be a valuable tool to further study the in vivo role of this adaptor protein and its involvement in molecular mechanisms of microglia homeostasis (Stoecker 2009)