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FLASH GENE

Symbol

STAP1

contributors: mct/npt - updated : 22-04-2009

HGNC name	signal transducing adaptor family member 1
HGNC id	24133

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed STAP1 9 - 1524 34 295 - Masuhara (2000)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Connective bone

cell lineage
cell lines	B cell lines Ramos highly
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a proline rich region
	a pleckstrin homology domain
	SH2 domain
	multiple tyrosine residues that are potential target sites for Src homology two domains

conjugated

PhosphoP

HOMOLOGY

interspecies

ortholog to murine Brdg1-pending

intraspecies

homolog to ortholog of BRDG1 (BCR downstream signaling 1) mediating Tec-kinase signaling after cross-linking of the B-cell receptor

Homologene

FAMILY

protein-tyrosine kinases family

CATEGORY

adaptor , signaling , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	functioning as a docking protein acting downstream of TEC tyrosine kinase in B cell antigen receptor signaling
	participating in a positive feedback loop by increasing the activity of TEC
	playing a role in pro-inflammatory microglia activation potentially contributing to neuronal apoptosis and degeneration (Stoecker 2009)
	may control the recruitment of signaling kinases to receptor tyrosine kinases in different cell types (Stoecker 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense , cellular trafficking transport

text	humoral defense mechanism
	intracellular protein traffic

PATHWAY

metabolism

signaling

signal transduction

BCR signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

kinase domain of TEC

cell & other

REGULATION

Other	phosphorylated by TEC on tyrosine residues
	phosphorylated in response to BCR stimulation

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	potential candidate for therapeutic modulation of microglia activity and molecular target for limiting microglia activation in neurodegenerative disorders(Stoecker 2009)

ANIMAL & CELL MODELS

STAP-1-deficient mice will be a valuable tool to further study the in vivo role of this adaptor protein and its involvement in molecular mechanisms of microglia homeostasis (Stoecker 2009)