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FLASH GENE
Symbol SRP54 contributors: - updated : 27-12-2004
HGNC name signal recognition particle 54kDa
HGNC id 11301
Location 14q12-q13      Physical location : 35.452.103 - 35.498.771
DNA
TYPE functioning gene
STRUCTURE 46.00 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D14S262 - D14S1071 - D14S1034 - D14S1049 - BAZ1A - SRP54 - NFKBIA - MBIP - FOXA1 - D14S875 - D14S286 - D14S278 - D14S1039
Physical map
EGLN3 14q12 egl nine homolog 3 (C. elegans) C14orf147 14q13.1 chromosome 14 open reading frame 147 LOC122585 14q13.1 similar to 60S ribosomal protein L23a C14orf11 14q13 chromosome 14 open reading frame 11 SNX6 14q12 sorting nexin 6 LOC390465 14 similar to 60S ribosomal protein L23a CFL2 14q12-q13 cofilin 2 (muscle) LOC387982 14 similar to 60S RIBOSOMAL PROTEIN L12 BAZ1A 14q12-q13 bromodomain adjacent to zinc finger domain, 1A LOC390466 14 similar to SMT3 suppressor of mif two 3 homolog 2 LOC338902 14q13.2 similar to Immunoglobulin-binding protein 1 (CD79a-binding protein 1) (B cell signal transduction molecule alpha 4) (Alpha 4 protein) SRP54 14q12-q13 signal recognition particle 54kDa C14orf24 14q13.2 chromosome 14 open reading frame 24 C14orf10 14q12 chromosome 14 open reading frame 10 KIAA0391 14q13.1-q21.2 chromosome 14 open reading frame 10 CDC10P 14 CDC10 cell division cycle 10 homolog (S. cerevisiae) pseudogene MRP63P8 14q13.2 mitochondrial ribosomal protein 63 pseudogene 8 PSMA6 14q13 proteasome (prosome, macropain) subunit, alpha type, 6 LOC122589 14q13.2 similar to 60S acidic ribosomal protein P0 (L10E) NFKBIA 14q13 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha DNAJC8P1 14 DnaJ (Hsp40) homolog, subfamily C, member 8 pseudogene 1 LOC387983 14 LOC387983 LOC390467 14 similar to 40S RIBOSOMAL PROTEIN S3A (V-FOS TRANSFORMATION EFFECTOR PROTEIN) LOC122592 14q13.2 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) INSM2 14q13.1 insulinoma-associated 2 LOC387984 14 similar to GARNL1 protein GARNL1 14q13.2 GTPase activating RANGAP domain-like 1 LOC341835 14q13.2 similar to glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 NUTF2P2 14 nuclear transport factor 2 pseudogene 2 BRMS1L 14q13.2 breast cancer metastasis-suppressor 1-like LOC390468 14 similar to Plasmodium falciparum trophozoite antigen r45-like protein
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal GTPase domain
  • a NG domain forming a substantial part of the binding site for the signal sequence
  • a C terminal domain binding the 7s RNA
  • mono polymer heteromer , monomer , dimer
    HOMOLOGY
    interspecies homolog to C.elegans f21D5-7
    Homologene
    FAMILY Srp family of GTP-binding proteins
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • binding to the signal sequence of secretory and membrane proteins when they emerge from the ribosome and transferring them to translocating chain-associating membrane protein
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • subunit of the signal recognition particle (SRP) which is a ribonucleoprotein complex(SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9)
  • INTERACTION
    DNA
    RNA binding to the S domain of 7S RNA SRP19 dependent
    small molecule
    protein
  • binding to SRPR
  • binding to SRP19
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS