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FLASH GENE
Symbol SRP54 contributors: - updated : 27-12-2004
HGNC name signal recognition particle 54kDa
HGNC id 11301
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal GTPase domain
  • a NG domain forming a substantial part of the binding site for the signal sequence
  • a C terminal domain binding the 7s RNA
  • mono polymer heteromer , monomer , dimer
    HOMOLOGY
    interspecies homolog to C.elegans f21D5-7
    Homologene
    FAMILY Srp family of GTP-binding proteins
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • binding to the signal sequence of secretory and membrane proteins when they emerge from the ribosome and transferring them to translocating chain-associating membrane protein
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • subunit of the signal recognition particle (SRP) which is a ribonucleoprotein complex(SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9)
  • INTERACTION
    DNA
    RNA binding to the S domain of 7S RNA SRP19 dependent
    small molecule
    protein
  • binding to SRPR
  • binding to SRP19
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS