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FLASH GENE
Symbol SRP54 contributors: mct - updated : 26-01-2021
HGNC name signal recognition particle 54kDa
HGNC id 11301
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal GTPase domain, with an RNA-bound conformation of the SRP54 GTPase domain, in which the domain is spatially well separated from the signal peptide binding site
  • a NG domain forming a substantial part of the binding site for the signal sequence
  • a signal sequence-binding domain (M domain), which can also be regarded as a chaperone that prevents unfavorable interactions of the hydrophobic signal peptide
  • a C terminal domain binding the 7s RNA
    • mono polymer heteromer , monomer , dimer
    HOMOLOGY
    interspecies homolog to C.elegans f21D5-7
    Homologene
    FAMILY Srp family of GTP-binding proteins
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • binding to the signal sequence of secretory and membrane proteins when they emerge from the ribosome and transferring them to translocating chain-associating membrane protein
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • subunit of the signal recognition particle (SRP) which is a ribonucleoprotein complex(SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9)
    • INTERACTION
    DNA
    RNA binding to the S domain of 7S RNA SRP19 dependent
    small molecule
    protein
  • binding to SRPR
  • binding to SRP19
  • SRP54 interacted with both DDX58 and IFIH1 and impaired their association with MAVS
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NSC8
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS