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FLASH GENE
Symbol SPIB contributors: mct - updated : 19-11-2010
HGNC name Spi-B transcription factor (Spi-1/PU.1 related)
HGNC id 11242
Location 19q13.33      Physical location : 50.922.194 - 50.932.249
Synonym name transcription factor Spi-B
Synonym symbol(s) SPI-B
DNA
TYPE functioning gene
STRUCTURE 10.06 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
PNKP 19q13.3-q13.4 polynucleotide kinase 3'-phosphatase MGC2865 19q13.33 hypothetical protein MGC2865 FLJ12168 IL4I1 19q13.3-q13.4 interleukin 4 induced 1 NUP62 19q13.33 nucleoporin 62kDa ATF5 19q13.3 activating transcription factor 5 SIGLEC11 19q13.33 sialic acid binding Ig-like lectin 11 VRK3 19q13 vaccinia related kinase 3 ZNF473 19q13.33 zinc finger protein 473 LOC342917 19q13.33 similar to kruppel-related zinc finger protein MGC33947 19q13.33 hypothetical protein MGC33947 MYH14 19q13.33 myosin, heavy polypeptide 14 KCNC3 19q13.3 potassium voltage-gated channel, Shaw-related subfamily, member 3 NAP1L 19q13.33 potassium voltage-gated channel, Shaw-related subfamily, member 3 NAP1 19q13.33 pronapsin A NR1H2 19q13.3 nuclear receptor subfamily 1, group H, member 2 POLD1 19q13.3 polymerase (DNA directed), delta 1, catalytic subunit 125kDa SPIB 19q13.3 Spi-B transcription factor (Spi-1/PU.1 related) MYBPC2 19q13.3 myosin binding protein C, fast type LOC284361 19q13.33-q13.41 hypothetical protein LOC284361 SBBI54 19q13.41 hypothetical transmembrane protein SBBI54 LOC284363 19q13.41 similar to RIKEN cDNA 0610012D14 DKFZp761A179 SYT3 19q13.4 synaptotagmin III LOC342918 19q13.41 hypothetical LOC342918 SHANK1 19q13.3 SH3 and multiple ankyrin repeat domains 1 SCGF 19q13.3 stem cell growth factor; lymphocyte secreted C-type lectin GPR32P 19q13.3 G protein-coupled receptor 32, pseudogene GPR32 19q13.3 G protein-coupled receptor 32 ACPT 19q13.4 acid phosphatase, testicular MGC13170 19q13.41 multidrug resistance-related protein MGC45922 19q13.41 hypothetical gene MGC45922 KLK1 19q13.4 kallikrein 1, renal/pancreas/salivary KLK15 19q13.4 kallikrein 1, renal/pancreas/salivary KLK3 19q13.3 kallikrein 3, (prostate specific antigen) KLK2 19q13.4 kallikrein 2, prostatic KLK4 19q13.3-q13.4 kallikrein 4 (prostase, enamel matrix, prostate) LOC390956 19 similar to peptidyl-Pro cis trans isomerase KLK5 19q13.3-q13.4 kallikrein 5
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 splicing 1448 28.8 262 nuclear 1996 8670269
- splicing 1444 - 177 cytoplasmic 1996 8670269
also called DeltaSpi-B
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Cardiovascularheart    
Digestiveintestinesmall intestine   
Lymphoid/Immunelymph node    
 tonsils    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Lymphoid    
cell lineage various hematopoietic cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved ETS domain mediating specific DNA binding
  • a weakly acidic N-terminal transactivation domain (TAD)
  • a second TAD rich in proline, serine and threonine
  • HOMOLOGY
    interspecies ortholog to murine Spib
    homolog to C elegans C18E3.9
    intraspecies homolog to Spi-1/PU.1 putative oncogene
    Homologene
    FAMILY
  • SPI-group ETS-protein transcription factors family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    basic FUNCTION
  • regulating transcription from Pol II promoter
  • affecting SPIB function by recruiting factors involved in SPIB activity
  • key regulator of plasmacytoid dendritic cells development, whereas T-cell development is critically dependent on GATA3
  • implicated in signaling pathways downstream of the B cell receptor and is essential for germinal center formation and maintenance
  • playing a role in maintenance of germinal center and memory B cells by direct repression of major plasma cell factors and thereby plasma cell differentiation
  • may be contributes to plasmacytoid dendritic cells development by promoting TCF4 activity
  • important mediator of both B-cell receptor signaling and early T-cell lineage decisions
  • also induces the development of plasmacytoid dendritic cells and can mediate IL7R, REL and IFNG–induced CD40 expression
  • as specific transcription factors SPI1, and SPIC, regulate follicular B cell differentiation
  • SPI1 and SPIB are essential transcriptional regulators of B-cell differentiation as well as novel tumor suppressors in the B-cell lineage
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text transcription activator
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to a purine-rich sequence the PU box (5'-GAGGAA-3') acting as a
    lymphoid-specific enhancer
    RNA
    small molecule
    protein
  • interacting with IRF4 and with CREBBP, EP300, SPI1-related, JUN and TBP
  • direct target gene critically regulated by POU2AF1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to primary biliary cirrhosis
    Variant & Polymorphism SNP
  • rs3745516 within SPIB strongly associated with primary biliary cirrhosis
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice deficient in both Spib and Spi1 in the B-cell lineage had reduced frequencies of B cells as well as impaired B-cell differentiation, and developed pre-B cell acute lymphoblastic leukemia before 30 weeks of age